Evidence map›Paper›PMID 30270114›Full record

ArticleCell chemical biology2018

Profiling the Metabolism of Human Cells by Deep

Nina Grankvist, Jeramie D Watrous, Kim A Lagerborg, Yaroslav Lyutvinskiy, Mohit Jain, Roland Nilsson

Open access · bronzeAbstract read
In one paragraph

Article in Cell chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Use of Nuclear Magnetic Resonance (NMR) to Study Cancer Metabolism.Advances in experimental medicine and biology · 2026
    Review
  3. Article
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  6. GlobalNature metabolism · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Nina GrankvistCardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm 171 76, Sweden; Karolinska University Hospital, Stockholm 171 76, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm 171 76, Sweden.
Jeramie D WatrousDepartments of Medicine and Pharmacology, University of California, San Diego; 9500 Gilman Drive, La Jolla, CA 92093, USA.
Kim A LagerborgDepartments of Medicine and Pharmacology, University of California, San Diego; 9500 Gilman Drive, La Jolla, CA 92093, USA.
Yaroslav LyutvinskiyCardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm 171 76, Sweden; Karolinska University Hospital, Stockholm 171 76, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm 171 76, Sweden.
Mohit JainDepartments of Medicine and Pharmacology, University of California, San Diego; 9500 Gilman Drive, La Jolla, CA 92093, USA.
Roland NilssonCardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm 171 76, Sweden; Karolinska University Hospital, Stockholm 171 76, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm 171 76, Sweden. Electronic address: roland.nilsson@ki.se.
Karolinska University Hospital · SEUniversity of California San Diego · US

Funding

Mapping the Plasma Exposome and its Association with Human Cardiovascular DiseaseR01ES027595 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAIN, MOHIT · 2017 to 2021
$3.3M
RapidFire mass spectrometry systemS10OD020025 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAIN, MOHIT · 2015 to 2015
$600k
Mapping metabolic activities in stem cell-derived models of human cardiomyopathyR03HL133720 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAIN, MOHIT · 2016 to 2017
$155k
NHLBI NIH HHS R03 HL133720NIEHS NIH HHS R01 ES027595NIH HHS S10 OD020025
6 · The paper itself

Abstract

Studying metabolic activities in living cells is crucial for understanding human metabolism, but facile methods for profiling metabolic activities in an unbiased, hypothesis-free manner are still lacking. To address this need, we here introduce the deep-labeling method, which combines a custom

Indexed as

MetabolomeAmino Acids, Branched-ChainCarbon IsotopesCitric Acid CycleHCT116 CellsHumansIsotope LabelingMCF-7 CellsMetabolomicsNeoplasmsTandem Mass SpectrometryAmino Acids, Branched-ChainCarbon Isotopesbranched-chain amino acidscancer metabolismculture mediumendogenous metabolitesisotope tracingmass spectrometrymetabolomemetabolomicspathway activity

Identifiers

PMID30270114
PMCPMC6239935
OpenAlexW2893032201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.