Evidence map›Paper›PMID 30270110›Full record

ArticleMolecular cell2018

Impeding DNA Break Repair Enables Oocyte Quality Control.

Huanyu Qiao, H B D Prasada Rao, Yan Yun, Sumit Sandhu, Jared H Fong, Manali Sapre, Michael Nguyen, Addy Tham, Benjamin W Van, Tiffany Y H Chng and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Genetic control of meiosis surveillance mechanisms in mammals.Frontiers in cell and developmental biology · 2023
    Review
  19. MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Huanyu QiaoHoward Hughes Medical Institute, University of California, Davis, Davis, CA, USA; Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA. Electronic address: hqiao@illinois.edu.
H B D Prasada RaoHoward Hughes Medical Institute, University of California, Davis, Davis, CA, USA; Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA.
Yan YunHoward Hughes Medical Institute, University of California, Davis, Davis, CA, USA; Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA.
Sumit SandhuHoward Hughes Medical Institute, University of California, Davis, Davis, CA, USA; Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA.
Jared H FongHoward Hughes Medical Institute, University of California, Davis, Davis, CA, USA; Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA.
Manali SapreHoward Hughes Medical Institute, University of California, Davis, Davis, CA, USA; Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA.
Michael NguyenHoward Hughes Medical Institute, University of California, Davis, Davis, CA, USA; Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA.
Addy ThamHoward Hughes Medical Institute, University of California, Davis, Davis, CA, USA; Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA.
Benjamin W VanHoward Hughes Medical Institute, University of California, Davis, Davis, CA, USA; Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA.
Tiffany Y H ChngHoward Hughes Medical Institute, University of California, Davis, Davis, CA, USA; Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA.
Amy LeeHoward Hughes Medical Institute, University of California, Davis, Davis, CA, USA; Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA.
Neil HunterHoward Hughes Medical Institute, University of California, Davis, Davis, CA, USA; Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA; Department of Molecular & Cellular Biology, University of California, Davis, Davis, CA, USA; Department of Cell Biology & Human Anatomy, University of California, Davis, Davis, CA, USA. Electronic address: nhunter@ucdavis.edu.
Howard Hughes Medical Institute · US

Funding

Training Program in Oncogenic Signals and Chromosome BiologyT32CA108459 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HEYER, WOLF-DIETRICH · 2006 to 2020
$3.6M
Meiosis, SUMOylation and the ZIP3 Protein: Parallel Studies in Mouse and Yeast.R01GM084955 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HUNTER, NEIL · 2009 to 2012
$1.2M
Meiotic checkpoint pathways and gametocyte quality controlR00HD082375 · NICHD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI QIAO, HUANYU · 2017 to 2019
$674k
Meiotic checkpoint pathways and gametocyte quality controlK99HD082375 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI QIAO, HUANYU · 2015 to 2016
$178k
Howard Hughes Medical InstituteNCI NIH HHS T32 CA108459NICHD NIH HHS K99 HD082375NICHD NIH HHS R00 HD082375NIGMS NIH HHS R01 GM084955
6 · The paper itself

Abstract

Oocyte quality control culls eggs with defects in meiosis. In mouse, oocyte death can be triggered by defects in chromosome synapsis and recombination, which involve repair of DNA double-strand breaks (DSBs) between homologous chromosomes. We show that RNF212, a SUMO ligase required for crossing over, also mediates oocyte quality control. Both physiological apoptosis and wholesale oocyte elimination in meiotic mutants require RNF212. RNF212 sensitizes oocytes to DSB-induced apoptosis within a narrow window as chromosomes desynapse and cells transition into quiescence. Analysis of DNA damage during this transition implies that RNF212 impedes DSB repair. Consistently, RNF212 is required for HORMAD1, a negative regulator of inter-sister recombination, to associate with desynapsing chromosomes. We infer that oocytes impede repair of residual DSBs to retain a "memory" of meiotic defects that enables quality-control processes. These results define the logic of oocyte quality control and suggest RNF212 variants may influence transmission of defective genomes.

Indexed as

AnimalsCell Cycle ProteinsChromosome PairingDNA Breaks, Double-StrandedDNA DamageDNA RepairFemaleLigasesMaleMeiosisMiceOocytesQuality ControlRecombination, GeneticCell Cycle ProteinsLigasesapoptosisattritiondouble strand breakfolliclehomologous recombinationHORMADmeiosisoocyteRNF212SUMO

Identifiers

PMID30270110
PMCPMC6426715
OpenAlexW2952881508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.