ArticleNeuron2018
γ-Neurexin and Frizzled Mediate Parallel Synapse Assembly Pathways Antagonized by Receptor Endocytosis.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 79 citations in OpenAlex.
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- Roles of NRXN1 in neuropsychiatric disorders: from genetic lesion to molecular mechanism.Frontiers in neuroscience · 2026Review
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- A modular system to label endogenous presynaptic proteins using split fluorophores in Caenorhabditis elegans.Genetics · 2025Article
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- Intracellular protein-lipid interactions drive presynaptic assembly prior to neurexin recruitment.Neuron · 2025Article
- Conserved autism-associated genes tune social feeding behavior in C. elegans.Nature communications · 2024Article
- nlr-1/CNTNAP regulates dopamine circuit structure and foraging behaviors in C. elegans.Communications biology · 2024Article
- Using Localization Microscopy to Quantify Calcium Channels at Presynaptic Boutons.Bio-protocol · 2024Article
- Neurexin drives Caenorhabditis elegans avoidance behavior independently of its post-synaptic binding partner neuroligin.G3 (Bethesda, Md.) · 2024Article
- Neuronal and non-neuronal functions of the synaptic cell adhesion molecule neurexin in Nematostella vectensis.Nature communications · 2024Article
- Versatile nanobody-based approach to image, track and reconstitute functional Neurexin-1 in vivo.Nature communications · 2024Article
- Structural neuroplasticity after sleep loss modifies behavior and requires neurexin and neuroligin.iScience · 2024Article
- Article
- Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly.PLoS biology · 2024Article
- Conserved autism-associated genes tune social feeding behavior inbioRxiv : the preprint server for biology · 2023Article
- Distinct neurexin isoforms cooperate to initiate and maintain foraging activity.Translational psychiatry · 2023Article
- Protein-lipid interactions drive presynaptic assembly upstream of cell adhesion molecules.bioRxiv : the preprint server for biology · 2023Article
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8 authors at 4 institutions in 1 country.
Funding
Abstract
Synapse formation defines neuronal connectivity and is thus essential for neuronal circuit assembly. Trans-synaptic interactions of cell adhesion molecules are thought to induce synapse assembly. Here we demonstrate that a recently discovered and conserved short form of neurexin, γ-neurexin, which lacks canonical extracellular domains, is nonetheless sufficient to promote presynaptic assembly in the nematode C. elegans. γ- but not α-neurexin is required for assembling active zone components, recruiting synaptic vesicles, and clustering calcium channels at release sites to promote evoked synaptic transmission. Furthermore, we find that neurexin functions in parallel with the transmembrane receptor Frizzled, as the absence of both proteins leads to an enhanced phenotype-the loss of most synapses. Frizzled's pro-synaptogenic function is independent of its ligand, Wnt. Wnt binding instead eliminates synapses by inducing Frizzled's endocytosis and the downregulation of neurexin. These results reveal how pro- and anti-synaptogenic factors converge to precisely sculpt circuit formation in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.