Evidence map›Paper›PMID 30269917›Full record

ArticleVaccine2018

Evaluation of a conjugate vaccine platform against enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni and Shigella.

Renee M Laird, Zuchao Ma, Nelum Dorabawila, Brittany Pequegnat, Eman Omari, Yang Liu, Alexander C Maue, Steven T Poole, Milton Maciel, Kavyashree Satish and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
  3. Recent progress in enterotoxigenicInfection and immunity · 2025
    Review
  4. Review
  5. Review
  6. International journal of molecular sciences · 2024
    Review
  7. Review
  8. Review
  9. Article
  10. Recent Progress inPathogens (Basel, Switzerland) · 2021
    Review
  11. Review
  12. Review
  13. An AttenuatedFrontiers in veterinary science · 2020
    Article
  14. Article
  15. Enterotoxigenic Escherichia coli Infections.Current infectious disease reports · 2019
    Review
  16. Article
  17. Classical and novel strategies to develop aHuman vaccines & immunotherapeutics · 2019
    Review
  18. Evaluation of a RecombinantFrontiers in immunology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Renee M LairdHenry M. Jackson Foundation for Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA; Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA. Electronic address: renee.m.laird.ctr@mail.mil.
Zuchao MaDepartment of Chemistry, University of Guelph, 50 Stone Road E, Guelph, Ontario N1G 2W1, Canada.
Nelum DorabawilaHenry M. Jackson Foundation for Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA; Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Brittany PequegnatDepartment of Chemistry, University of Guelph, 50 Stone Road E, Guelph, Ontario N1G 2W1, Canada.
Eman OmariDepartment of Chemistry, University of Guelph, 50 Stone Road E, Guelph, Ontario N1G 2W1, Canada.
Yang LiuHenry M. Jackson Foundation for Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA; Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Alexander C MaueHenry M. Jackson Foundation for Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA; Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Steven T PooleHenry M. Jackson Foundation for Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA; Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Milton MacielHenry M. Jackson Foundation for Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA; Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Kavyashree SatishHenry M. Jackson Foundation for Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA; Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Christina L GariepyHenry M. Jackson Foundation for Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA; Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Nina M SchumackHenry M. Jackson Foundation for Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA; Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Annette L McVeighHenry M. Jackson Foundation for Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA; Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Frédéric PolyEnteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Cheryl P EwingHenry M. Jackson Foundation for Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA; Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Michael G ProutyEnteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Mario A MonteiroDepartment of Chemistry, University of Guelph, 50 Stone Road E, Guelph, Ontario N1G 2W1, Canada.
Stephen J SavarinoEnteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Patricia GuerryEnteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA. Electronic address: patriciaguerry@yahoo.com.
Naval Medical Research Command · USUniversity of Guelph · CAHenry M. Jackson Foundation · US

Funding

Capsule conjugate vaccines against ETEC and CampylobacterR01AI089449 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI GUERRY, PATRICIA · 2010 to 2014
$2.9M
NIAID NIH HHS R01 AI089449
6 · The paper itself

Abstract

Enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni (CJ), and Shigella sp. are major causes of bacterial diarrhea worldwide, but there are no licensed vaccines against any of these pathogens. Most current approaches to ETEC vaccines are based on recombinant proteins that are involved in virulence, particularly adhesins. In contrast, approaches to Shigella and CJ vaccines have included conjugate vaccines in which Shigella lipopolysaccharides (LPS) or CJ capsule polysaccharides are chemically conjugated to proteins. We have explored the feasibility of developing a multi-pathogen vaccine by using ETEC proteins as conjugating partners for CJ and Shigella polysaccharides. We synthesized three vaccines in which two CJ polysaccharides were conjugated to two recombinant ETEC adhesins based on CFA/I (CfaEB) and CS6 (CssBA), and LPS from Shigella flexneri was also conjugated to CfaEB. The vaccines were immunogenic in mice as monovalent, bivalent and trivalent formulations. Importantly, functional antibodies capable of inducing hemaglutination inhibition (HAI) of a CFA/I expressing ETEC strain were induced in all vaccines containing CfaEB. These data suggest that conjugate vaccines could be a platform for a multi-pathogen, multi-serotype vaccine against the three major causes of diarrheal disease worldwide.

Indexed as

AnimalsCampylobacter jejuniEnterotoxigenic Escherichia coliEnzyme-Linked Immunosorbent AssayHemagglutination Inhibition TestsMiceMice, Inbred BALB CShigellaVaccines, ConjugateVaccines, ConjugateCampylobacterConjugate vaccinesETECFunctional antibodiesShigella

Identifiers

PMID30269917
PMCPMC6223012
OpenAlexW2893533628

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.