Evidence map›Paper›PMID 30269666›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2019

Seizure predictors and outcome after Onyx embolization in patients with brain arteriovenous malformations.

Baorui Zhang, Xin Feng, Fei Peng, Luyao Wang, Er Kang Guo, Yupeng Zhang, Peng Liu, Zhongxue Wu, Aihua Liu

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Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Baorui Zhang1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Xin Feng1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Fei Peng1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Luyao Wang1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Er Kang Guo1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Yupeng Zhang1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Peng Liu1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Zhongxue Wu1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Aihua Liu1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Capital Medical University · CNBeijing Institute of Neurosurgery · CNBeijing Tian Tan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBrain arteriovenous malformation (bAVM)-related epilepsy can significantly affect patient quality of life. We aimed to identify the factors associated with seizures occurrence and evaluate the long-term outcome following Onyx embolization in bAVM patients.

methodsBetween July 2014 and July 2016, 239 consecutive patients underwent treatment for bAVMs in our institute and were respectively analyzed. Demographics, seizure status and bAVM morphologic characteristics were recorded. Modified Engel classification was used to evaluate the long-term seizure outcomes.

resultsOf 239 bAVM patients, 68 (28.5%) initially presented with seizures. Seizure occurrence was associated with cerebral hemorrhage history, frontal-temporal location and arterial borderzone location. Of the 37 patients who presented with initial seizures and were treated with Onyx embolization, 23 (62.2%) were treated with antiepileptic drugs (AEDs) before Onyx embolization. At the last follow-up visit, 19 (51.4%) of the 37 patients reached modified Engel class I outcome. Of the 23 patients who had ever been treated with AEDs, 12 (52.2%) were still taking AEDs at the last follow-up visit. Single-factor analysis showed that arterial borderzone location was significantly correlated with higher modified Engel class outcome ( p = 0.046).

conclusionPatients with bAVM hemorrhage history, frontal-temporal location and arterial borderzone location were associated with seizure occurrence. Seizure-free status was not obtained in AVM patients with arterial borderzone after embolization, though it may have benefits in other ways. The seizure-free mechanism of bAVM with Onyx embolization is worth further study.

Indexed as

AdolescentAdultAngiography, Digital SubtractionCerebral AngiographyChildChild, PreschoolDimethyl SulfoxideEmbolization, TherapeuticEpilepsyFemaleHumansIntracranial Arteriovenous MalformationsMaleMiddle AgedPolyvinylsQuality of LifeDimethyl SulfoxideOnyx copolymerPolyvinylsArteriovenous malformationembolizationepilepsyseizure

Identifiers

PMID30269666
PMCPMC6448384
OpenAlexW2895683443

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.