Trial reportClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2019
Ratios of specific IgG
Trial report in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Precision Medicine in Plant Food Allergy: a Systematic Review of Biomarkers Under a Clinical Approach.Clinical reviews in allergy & immunology · 2026Pooled it
- Risk factors for severe reactions in food allergy: Rapid evidence review with meta-analysis.Allergy · 2022Pooled it
- Trial
- Insulin allergy: a diagnostic and therapeutic strategy based on a retrospective cohort and a case-control study.Diabetologia · 2022Trial
- Ratios of specific IgGClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Analysis of Specific IgG4 Antibody and sIgG4/sIgE Antibody Ratio as Marker of Immune Tolerance to IgE-Mediated Response in Allergic Children.Children (Basel, Switzerland) · 2025Article
- Saliva antibody profiles are associated with reaction threshold and severity of peanut allergic reactions.The Journal of allergy and clinical immunology · 2024Article
- Phage Immunoprecipitation Sequencing (PhIP-Seq) for Analyzing Antibody Epitope Repertoires Against Food Antigens.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Exploratory immunogenicity outcomes of peanut oral immunotherapy: Findings from the PALISADE trial.Clinical and translational allergy · 2024Article
- Revealing clinically relevant specific IgE sensitization patterns in Hymenoptera venom allergy with dimension reduction and clustering.The World Allergy Organization journal · 2023Article
- Developing a Prediction Model for Determination of Peanut Allergy Status in the Learning Early About Peanut Allergy (LEAP) Studies.The journal of allergy and clinical immunology. In practice · 2023Article
- Allergenic food protein consumption is associated with systemic IgG antibody responses in non-allergic individuals.Immunity · 2022Article
- New Mechanistic Advances in FcεRI-Mast Cell-Mediated Allergic Signaling.Clinical reviews in allergy & immunology · 2022Review
- Impact of Food Matrices on Digestibility of Allergens and Poorly Allergenic Homologs.Frontiers in allergy · 2022Article
- Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA).Clinical and translational allergy · 2021Review
- Estimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles.Frontiers in allergy · 2021Article
- Allergic Rhinitis: What Do We Know About Allergen-Specific Immunotherapy?Frontiers in allergy · 2021Review
- Grand Challenges in Food Allergy.Frontiers in allergy · 2021Article
- B cells and the microbiota: a missing connection in food allergy.Mucosal immunology · 2021Review
- Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.Allergy · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIgG
objectiveTo evaluate whether (a) peanut-specific IgG, IgG
methodsSera of 137 patients with challenge-proven peanut allergy and of 25 subjects that tolerated peanut, both with known IgE profiles to peanut extract and five individual peanut allergens, were analyzed for specific IgG and IgG
resultsIgE against Ara h 2 was significantly higher in allergic than in tolerant patients and associated with severity of reactions (P < 0.001) with substantial diagnostic capability (AUC 0.91, 95%CI 0.87-0.96 and 0.80, 95%CI 0.73-0.87, respectively). IgG and IgG
conclusionIgE against Ara h 2 is the best biomarker for predicting peanut challenge outcomes including severity and IgG and IgG
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.