Evidence map›Paper›PMID 30269307›Full record

ArticleCancer causes & control : CCC2018

Benign gynecologic conditions are associated with ovarian cancer risk in African-American women: a case-control study.

Hyo K Park, Joellen M Schildkraut, Anthony J Alberg, Elisa V Bandera, Jill S Barnholtz-Sloan, Melissa Bondy, Sydnee Crankshaw, Ellen Funkhouser, Patricia G Moorman, Edward S Peters and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Appraisal of the causal effect ofmedRxiv : the preprint server for health sciences · 2024
    Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Hyo K ParkDepartment of Oncology and the Karmanos Cancer Institute, Population Studies and Disparities Research Program, Wayne State University School of Medicine, 4100 John R. Mailcode: MM04EP, Detroit, MI, 48201, USA. hpar@med.wayne.edu.
Joellen M SchildkrautDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Anthony J AlbergHollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Elisa V BanderaDepartment of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Jill S Barnholtz-SloanCase Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Melissa BondyCancer Prevention and Population Sciences Program, Baylor College of Medicine, Houston, TX, USA.
Sydnee CrankshawDepartment of Community and Family Medicine, Cancer Control and Population Sciences, Duke University School of Medicine, Durham, NC, USA.
Ellen FunkhouserDivision of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Patricia G MoormanDepartment of Community and Family Medicine, Cancer Control and Population Sciences, Duke University School of Medicine, Durham, NC, USA.
Edward S PetersEpidemiology Program, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA, USA.
Paul TerryDepartment of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA.
Frances WangDepartment of Community and Family Medicine, Cancer Control and Population Sciences, Duke University School of Medicine, Durham, NC, USA.
Julie J RuterbuschDepartment of Oncology and the Karmanos Cancer Institute, Population Studies and Disparities Research Program, Wayne State University School of Medicine, 4100 John R. Mailcode: MM04EP, Detroit, MI, 48201, USA.
Ann G SchwartzDepartment of Oncology and the Karmanos Cancer Institute, Population Studies and Disparities Research Program, Wayne State University School of Medicine, 4100 John R. Mailcode: MM04EP, Detroit, MI, 48201, USA.
Michele L CoteDepartment of Oncology and the Karmanos Cancer Institute, Population Studies and Disparities Research Program, Wayne State University School of Medicine, 4100 John R. Mailcode: MM04EP, Detroit, MI, 48201, USA.
Duke University · USThe Barbara Ann Karmanos Cancer Institute · USBaylor College of Medicine · USCase Western Reserve University · USLouisiana State University Health Sciences Center New Orleans · USMUSC Hollings Cancer Center · USRutgers, The State University of New Jersey · USUniversity of Alabama at Birmingham · USUniversity of Tennessee at Knoxville · USUniversity of Virginia · USWayne State University · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
NEW JERSEY CANCER PREVENTION & CONTROL PROGRAMU58DP003931 · DP · NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS · PI RODRIQUEZ, GLORIA · 2012 to 2014
$11.9M
Epidemiology of Ovarian Cancer in African-American WomenR01CA142081 · NCI · UNIVERSITY OF VIRGINIA · PI SCHILDKRAUT, JOELLEN M. · 2010 to 2015
$10.6M
NCCDPHP CDC HHS U58 DP003931NCI NIH HHS HHSN261201000028CNCI NIH HHS P30 CA022453NCI NIH HHS R01 CA142081NCI NIH HHS R01CA142081
6 · The paper itself

Abstract

backgroundThe association between common benign gynecologic conditions and ovarian cancer remains under-studied in African Americans. Therefore, we examine the association between self-reported history of benign gynecologic conditions and epithelial ovarian cancer risk in African-American women.

methodsData from a large population-based, multi-center case-control study of epithelial ovarian cancer in African-American women were analyzed to estimate the association between self-reported history of endometriosis, pelvic inflammatory disease (PID), fibroid, and ovarian cyst with epithelial ovarian cancer. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the associations between individual and composite gynecologic conditions and ovarian cancer.

results600 cases and 752 controls enrolled in the African American Cancer Epidemiology Study between 1 December 2010 and 31 December 2015 comprised the study population. After adjusting for potential confounders, a history of endometriosis was associated with ovarian cancer (OR 1.78; 95% CI 1.09-2.90). A non-significant association of similar magnitude was observed with PID (OR 1.33; 95% CI 0.82-2.16), while no association was observed in women with a history of fibroid or ovarian cyst. A positive trend was observed for an increasing number of reported gynecologic conditions (p = 0.006) with consistency across histologic subtypes and among both oral contraceptive users and non-users.

conclusionA self-reported history of endometriosis among African-American women was associated with increased risk of ovarian cancer. Having multiple benign gynecologic conditions also increased ovarian cancer risk.

Indexed as

AdultAgedBlack or African AmericanCarcinoma, Ovarian EpithelialCase-Control StudiesEndometriosisFemaleGenital Diseases, FemaleHumansLeiomyomaLogistic ModelsMiddle AgedOdds RatioOvarian CystsOvarian NeoplasmsPelvic Inflammatory DiseaseAfrican-AmericanAfrican-American Cancer Epidemiology Study (AACES)EndometriosisOvarian cancerOvarian cystPelvic inflammatory disease (PID)Uterine fibroid

Identifiers

PMID30269307
PMCPMC6230481
OpenAlexW2893072997

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.