Evidence map›Paper›PMID 30269276›Full record

Trial reportCancer chemotherapy and pharmacology2018

Relationship between folate concentration and expression of folate-associated genes in tissue and plasma after intraoperative administration of leucovorin in patients with colorectal cancer.

Helena Taflin, Elisabeth Odin, Kristoffer Derwinger, Göran Carlsson, Bengt Gustavsson, Yvonne Wettergren

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer chemotherapy and pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Helena TaflinDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital/Östra, Sahlgrenska Academy at University of Gothenburg, 41685, Gothenburg, Sweden. helena.taflin@vgregion.se.ORCID 0000-0002-8795-5250
Elisabeth OdinDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital/Östra, Sahlgrenska Academy at University of Gothenburg, 41685, Gothenburg, Sweden.
Kristoffer DerwingerDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital/Östra, Sahlgrenska Academy at University of Gothenburg, 41685, Gothenburg, Sweden.
Göran CarlssonDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital/Östra, Sahlgrenska Academy at University of Gothenburg, 41685, Gothenburg, Sweden.
Bengt GustavssonDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital/Östra, Sahlgrenska Academy at University of Gothenburg, 41685, Gothenburg, Sweden.
Yvonne WettergrenDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital/Östra, Sahlgrenska Academy at University of Gothenburg, 41685, Gothenburg, Sweden.
Sahlgrenska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of study was to investigate the relationship between folate concentration and expression of folate-associated genes in tumour, mucosa and plasma of patients with colorectal cancer, after intraoperative administration of bolus leucovorin (LV).

methodsEighty patients were randomized into four groups to receive 0, 60, 200, or 500 mg/m

resultsThe folate concentration in tumour increased with increasing dosage of LV. Half of the patients treated with 60 mg/m

conclusionsThe results indicate the possibility of using the individual plasma 5-MTHF/LV ratio after LV injection as a surrogate marker for tissue folate concentration. Expression of several folate-associated genes is associated with folate concentration in tissue and plasma and may become useful when predicting response to LV treatment.

Indexed as

Intraoperative CareTetrahydrofolatesAdultAgedAged, 80 and overColorectal NeoplasmsDose-Response Relationship, DrugFemaleGene Expression ProfilingHumansInjections, IntravenousLeucovorinMaleMiddle Aged5-methyltetrahydrofolateLeucovorinTetrahydrofolatesColorectal cancerFolateGene expressionPCFTRFC-1

Identifiers

PMID30269276
PMCPMC6267663
OpenAlexW2894276513

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.