Evidence map›Paper›PMID 30269157›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2019

Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy.

Valentina Garibotto, Michael Wissmeyer, Zoi Giavri, Rachel Goldstein, Yann Seimbille, Margitta Seeck, Osman Ratib, Sven Haller, Fabienne Picard

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Valentina GaribottoNuclear Medicine and Molecular Imaging Division, Department of Medical Imaging, University Hospitals of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Genève 14, Switzerland. valentina.garibotto@hcuge.ch.ORCID 0000-0003-2422-698X
Michael WissmeyerNuclear Medicine and Molecular Imaging Division, Department of Medical Imaging, University Hospitals of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Genève 14, Switzerland.
Zoi GiavriAdvantis Medical Imaging, Eindhoven, The Netherlands.
Rachel GoldsteinEEG and Epilepsy Unit, Department of Neurology, University Hospitals of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Genève 14, Switzerland.
Yann SeimbilleNuclear Medicine and Molecular Imaging Division, Department of Medical Imaging, University Hospitals of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Genève 14, Switzerland.
Margitta SeeckFaculty of Medicine, Geneva University, 1211, Geneva, Switzerland.
Osman RatibNuclear Medicine and Molecular Imaging Division, Department of Medical Imaging, University Hospitals of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Genève 14, Switzerland.
Sven HallerFaculty of Medicine, Geneva University, 1211, Geneva, Switzerland.
Fabienne PicardFaculty of Medicine, Geneva University, 1211, Geneva, Switzerland. Fabienne.Picard@hcuge.ch.
University of Geneva · CH

Funding

Swiss National Science Foundation 320030_127608
6 · The paper itself

Abstract

purposeMutations of cholinergic neuronal nicotinic receptors have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), associated with changes on PET images using [

methodsWe included 34 male participants, 12 patients with idiopathic generalized epilepsy (IGE), 10 with non-lesional diurnal focal epilepsy, and 12 age-matched healthy controls. All patients underwent PET/CT using F-A-85380 and [

resultsIn the group of patients with IGE, the voxel-wise and VOI analyses showed a significant increase of F-A-85380 ratio index of binding potential (BP

conclusionsWe observed focal changes of density/availability of nicotinic receptors in IGE, namely an increase in the ACC. These data suggest that the modulation of α4β2 nicotinic receptors plays a role not only in ADNFLE, but also in other genetic epileptic syndromes such as IGE and could serve as a biomarker of epilepsy syndromes with a genetic background.

Indexed as

AdolescentAdultBiomarkersCase-Control StudiesEpilepsy, GeneralizedFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMiddle AgedPositron Emission Tomography Computed TomographyReceptors, NicotinicYoung AdultBiomarkersReceptors, NicotinicF-A-85380Focal epilepsyIdiopathic generalized epilepsyNicotinic receptorsPET

Identifiers

PMID30269157
OpenAlexW2893518300

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.