ReviewCurrent opinion in chemical biology2019
Biocatalytic hydrogen atom transfer: an invigorating approach to free-radical reactions.
Review in Current opinion in chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Discovery of an Antiviral Electron Transfer Process to Create Catalytically Self-Sufficient Viral Restriction Factors.Angewandte Chemie (International ed. in English) · 2026Article
- Local Electric Fields Originate Unusual Kinetic Isotope Effects in the Hydrogen Abstraction Reactions of the Functionally Analogous P450 and TauD Enzymes.Journal of the American Chemical Society · 2025Article
- Article
- Photobiocatalytic Enantioselective Benzylic C(spJournal of the American Chemical Society · 2025Article
- Review
- The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe(II)/2-Oxoglutarate Histone Demethylase KDM2A.Inorganic chemistry · 2024Article
- Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH.Chemical science · 2024Article
- Regiodivergent Radical Termination for Intermolecular Biocatalytic C-C Bond Formation.Journal of the American Chemical Society · 2024Article
- Catalytic Asymmetric Hydrogen Atom Transfer: Enantioselective Hydroamination of Alkenes.Journal of the American Chemical Society · 2023Article
- Radical Activation of N-H and O-H Bonds at Bismuth(II).Journal of the American Chemical Society · 2022Article
- The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions.Journal of the American Chemical Society · 2021Article
- Activation modes in biocatalytic radical cyclization reactions.Journal of industrial microbiology & biotechnology · 2021Review
- Power of Biocatalysis for Organic Synthesis.ACS central science · 2021Review
- Active-Site Environmental Factors Customize the Photophysics of Photoenzymatic Old Yellow Enzymes.The journal of physical chemistry. B · 2020Article
- Photoenzymatic Generation of Unstabilized Alkyl Radicals: An Asymmetric Reductive Cyclization.Journal of the American Chemical Society · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Initiating and terminating free-radical reactionis via hydrogen atom transfer (HAT) is an attractive means of avoiding substrate prefunctionalization. Small molecule catalysts and reagents, however, struggle to execute this fundamental step with useful levels of diastereoselectivity and enantioselectivity. In contrast, nature often carries out HAT with exquisite levels of selectivity for even electronically unactivated carbon-hydrogen bonds. By understanding how enzymes exploit and control this fundamental step, new strategies can be developed to address several long-standing challenges in free-radical reactions. This review will cover recent discoveries in biocatalysis that exploit a HAT mechanism to either initiate or terminate novel one-electron reactions.
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Registered trials
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