ArticleNeuroImage. Clinical2018
White matter microstructure is associated with language in children born very preterm.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Prenatal Adversity and Neonatal White Matter Microstructure Independently Relate to Language Outcomes at Age 2 Years.The Journal of pediatrics · 2025Article
- Reading and White Matter Development: A Systematic Review of Neuroplastic Changes in Literacy.Children (Basel, Switzerland) · 2025Review
- Neonatal inflammation and near-term white matter microstructure in infants born very preterm.Neuroimage. Reports · 2024Article
- White and Gray Matter Abnormality in Burning Mouth Syndrome Evaluated with Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Article
- Association of in utero HIV exposure with child brain structure and language development: a South African birth cohort study.BMC medicine · 2024Article
- Multi-view fusion of diffusion MRI microstructural models: a preterm birth study.Frontiers in neuroscience · 2024Article
- Prenatal tobacco and alcohol exposure, white matter microstructure, and early language skills in toddlers from a South African birth cohort.Frontiers in integrative neuroscience · 2024Article
- Preterm birth and neonatal white matter microstructure in in-vivo reconstructed fiber tracts among audiovisual integration brain regions.Developmental cognitive neuroscience · 2023Article
- Applications of advanced diffusion MRI in early brain development: a comprehensive review.Brain structure & function · 2023Review
- Microstructural alterations in association tracts and language abilities in schoolchildren born very preterm and with poor fetal growth.Pediatric radiology · 2023Article
- Development of the Ontogenetic Self-Regulation Clock.International journal of molecular sciences · 2022Review
- Maturity of white matter tracts is associated with episodic memory recall during development.Cerebral cortex communications · 2022Article
- Diffusion MRI Microstructural Abnormalities at Term-Equivalent Age Are Associated with Neurodevelopmental Outcomes at 3 Years of Age in Very Preterm Infants.AJNR. American journal of neuroradiology · 2021Article
- Diffusion magnetic resonance imaging assessment of regional white matter maturation in preterm neonates.Neuroradiology · 2021Article
- Advances in functional and diffusion neuroimaging research into the long-term consequences of very preterm birth.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Discriminating VCID subgroups: A diffusion MRI multi-model fusion approach.Journal of neuroscience methods · 2020Review
- Scan-rescan and inter-vendor reproducibility of neurite orientation dispersion and density imaging metrics.Neuroradiology · 2020Article
- Conversational Language in 3-Year-Old Children Born Very Preterm and at Term.Journal of speech, language, and hearing research : JSLHR · 2020Article
- Neonatal white matter tract microstructure and 2-year language outcomes after preterm birth.NeuroImage. Clinical · 2020Article
- White matter microstructural abnormalities in children with severe congenital hypothyroidism.NeuroImage. Clinical · 2019Article
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Authors and funding
9 authors.
Funding
Abstract
Very preterm birth is associated with altered white matter microstructure and language difficulties, which may compromise communication, social function and academic achievement, but the relationship between these two factors is unclear. The aim of this study was to explore associations between white matter microstructure and language domains of semantics, grammar and phonological awareness at 7-years of age on a whole-brain level and within the arcuate fasciculus, an important language pathway, in very preterm and term-born children. Language was assessed in 145 very preterm-born (<30 weeks' gestation and/or <1250 g birth weight) and 33 term-born children aged 7 years. Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), mean diffusivity (MD), axon orientation dispersion and axon density were estimated from diffusion magnetic resonance images also obtained at 7 years. The correlation between diffusion values and language was assessed using Tract-Based Spatial Statistics (TBSS). The arcuate fasciculus was delineated using constrained spherical deconvolution tractography and diffusion parameters from this tract were related to language measures using linear regression. While there was evidence for widespread associations between white matter microstructure and language, there was little evidence of differences in these associations between very preterm and term-born groups. TBSS analyses revealed that higher FA and lower AD, RD, and MD in major fibre tracts, including those subserving language, were associated with better semantic, grammar and phonological awareness performance. Higher axon density in widespread fibre tracts was also associated with better semantic performance. The tractography analyses of the arcuate fasciculus showed some evidence for associations between white matter microstructure and language outcomes. White matter microstructural organisation in widespread fibre tracts, including language-relevant pathways, was associated with language performance in whole-brain and tract-based analyses. The associations were similar for very preterm and term-born groups, despite very preterm children performing more poorly across language domains.
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