Evidence map›Paper›PMID 30268819›Full record

ArticleSchizophrenia research2019

Differences in gut microbiome composition between persons with chronic schizophrenia and healthy comparison subjects.

Tanya T Nguyen, Tomasz Kosciolek, Yadira Maldonado, Rebecca E Daly, Averria Sirkin Martin, Daniel McDonald, Rob Knight, Dilip V Jeste

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 10 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 10 syntheses or guidelines pooled it, 252 citations in OpenAlex.

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  11. Trial
  12. Article
  13. Gut microbiota: contributing to high CVD prevalence in people living with schizophrenia?European archives of psychiatry and clinical neuroscience · 2026
    Review
  14. Article
  15. Review
  16. Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Article

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Tanya T NguyenDepartment of Psychiatry, University of California San Diego, CA, United States of America.
Tomasz KosciolekDepartment of Pediatrics, University of California San Diego, CA, United States of America.
Yadira MaldonadoSam and Rose Stein Institute for Research on Aging, University of California San Diego, CA, United States of America.
Rebecca E DalySam and Rose Stein Institute for Research on Aging, University of California San Diego, CA, United States of America.
Averria Sirkin MartinSam and Rose Stein Institute for Research on Aging, University of California San Diego, CA, United States of America.
Daniel McDonaldDepartment of Pediatrics, University of California San Diego, CA, United States of America.
Rob KnightDepartment of Pediatrics, University of California San Diego, CA, United States of America; Center for Microbiome Innovation, University of California San Diego, CA, United States of America; Department of Computer Science and Engineering, University of California San Diego, CA, United States of America.
Dilip V JesteDepartment of Psychiatry, University of California San Diego, CA, United States of America; Sam and Rose Stein Institute for Research on Aging, University of California San Diego, CA, United States of America; Center for Microbiome Innovation, University of California San Diego, CA, United States of America; Department of Neurosciences, University of California San Diego, CA, United States of America. Electronic address: djeste@ucsd.edu.
University of California, San Diego · USInstitute on Aging · US

Funding

FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
Accelerated Inflammaging in SchizophreniaR01MH094151 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EYLER, LISA T · 2012 to 2021
$7.4M
NIMH NIH HHS R01 MH094151NIMH NIH HHS T32 MH019934
6 · The paper itself

Abstract

Intestinal microbiome and gut-brain axis have been receiving increasing attention for their role in the regulation of brain/behavior and possible biological basis of psychiatric disorders. Several recent clinical studies have linked the microbiome with neuropsychiatric conditions, although the literature on schizophrenia is quite limited. This study investigated gut microbiome composition in 50 individuals, including 25 persons with chronic schizophrenia and 25 demographically-matched non-psychiatric comparison subjects (NCs). Stool samples were collected and assayed using 16S rRNA sequencing of the V4 region. Examination of unweighted UniFrac and Bray-Curtis dissimilarity revealed significant community-level separation in microbiome composition between the two subject groups. At the phylum level, Proteobacteria were found to be relatively decreased in schizophrenia subjects compared to NCs. At the genus level, Anaerococcus was relatively increased in schizophrenia while Haemophilus, Sutterella, and Clostridium were decreased. Within individuals with schizophrenia, abundance of Ruminococcaceae was correlated with lower severity of negative symptoms; Bacteroides was associated with worse depressive symptoms; and Coprococcus was related to greater risk for developing coronary heart disease. Our findings provide evidence of altered gut microbial composition in persons with chronic schizophrenia and suggest a need for larger and longitudinal studies of microbiome in schizophrenia.

Indexed as

Gastrointestinal MicrobiomeAdultChronic DiseaseFemaleHumansMaleMiddle AgedPsychotic DisordersSchizophreniaBacteriaGut-brain axisMicrobesPhylumProbioticsPsychosis

Identifiers

PMID30268819
PMCPMC6755901
OpenAlexW2892517180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.