ArticleJournal of the neurological sciences2018
Incident stroke among Ghanaians with hypertension and diabetes: A multicenter, prospective cohort study.
Article in Journal of the neurological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Development of a high-performing, cost-effective and inclusive Afrocentric predictive model for stroke: a meta-analysis approach.BMC neurology · 2025Pooled it
- Prevalence of Cardiovascular Disease and Risk Factors in Ghana: A Systematic Review and Meta-analysis.Global heart · 2024Pooled it
- A Systematic Review of the Burden of Stroke in Ghana.BioMed research international · 2024Pooled it
- Prevalence, awareness and control of hypertension in Ghana: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Quality of life indicators among recent Ghanaian stroke survivors across 10 hospitals: A cross-sectional study.Equity neuroscience · 2026Article
- Stroke burden and associated predictors in Ghana: a Bayesian analysis of the WHO study on global ageing and adult health.Aging clinical and experimental research · 2026Article
- Incidence and predictors of stroke among hypertension patients in Awi Zone public hospitals, Northwest Ethiopia: Retrospective follow-up study.BMC cardiovascular disorders · 2026Article
- Survival and predictors of mortality among adults with type 2 diabetes at a teaching hospital in Ghana: a retrospective cohort study.BMC public health · 2026Article
- Physiologic profiling using plasma renin activity and aldosterone on blood pressure control among Ghanaian stroke survivors: A pilot trial.Equity neuroscience · 2025Article
- Stroke in Ghana: A Situational Analysis.Stroke research and treatment · 2025Review
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- Health Interventions May Have Divergent Impacts on Health and Economic Equity: A Case Study of the Community-Based Hypertension Improvement Project in Ghana.Applied health economics and health policy · 2024Article
- Advanced Nano-Drug Delivery Systems in the Treatment of Ischemic Stroke.Molecules (Basel, Switzerland) · 2024Review
- Behavioural and nutritional risk factors for cardiovascular diseases among the Ghanaian population- a cross-sectional study.BMC public health · 2024Article
- The epidemiological and economic burden of diabetes in Ghana: A scoping review to inform health technology assessment.PLOS global public health · 2024Article
- Prevalence and predictors of low folate levels among stroke survivors in a country without mandatory folate food fortification: Analysis of a Ghanaian sample.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023Article
- Determinants of visit-to-visit systolic blood pressure variability among Ghanaians with hypertension and diabetes mellitus.Ghana medical journal · 2023Article
- Development and Validation of a Risk Prediction Model to Estimate the Risk of Stroke Among Hypertensive Patients in University of Gondar Comprehensive Specialized Hospital, Gondar, 2012 to 2022.Degenerative neurological and neuromuscular disease · 2023Article
- Computed tomography patterns of intracranial infarcts in a Ghanaian tertiary facility.Ghana medical journal · 2022Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe burden of stroke among hypertensive and diabetic population in sub-Saharan Africa remains high. We sought to identify the risk factors associated with stroke occurrence in these high-risk population groups.
methodsA prospective cohort study involving adults with hypertension and or type II diabetes mellitus at 5 public hospitals in Ghana who were stroke-free at enrollment. Patients were followed every 2 months at clinic for 18 months and assessed clinically for first ever stroke by physicians. We calculated crude incidence rates for stroke and assessed the factors associated with stroke occurrence using a multivariate Cox Proportional Hazards regression models.
resultsOf 3220 eligible participants with 3805 person-years of follow-up, there were 54 clinically confirmed new strokes. Incidence rate of stroke was 14.19 events per 1000 person-years [95% CI: 10.77-18.38], with rates among diabetics with hypertension being 16.64 [10.58-25.00], hypertension of 13.77 [9.33-19.64] and diabetes was 9.81 [3.59-21.74]. Two factors independently associated with stroke occurrence were previous cigarette smoking with adjusted HR (95% CI) of 2.59 (1.18-5.67) and physical inactivity, 1.81 (1.06-3.10). In secondary analysis, stage II hypertension compared with optimal BP was associated with aHR of 3.04 (1.00-9.27), p = .05 for stroke occurrence.
conclusionIncident stroke among Ghanaians with hypertension and diabetes is quite high. Stricter control of blood pressure and engaging in regular physical activities are strongly recommended to reduce the risk of strokes.
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