ArticleHeart, lung & circulation2019
Natural History of Persistent Pulmonary Subsolid Nodules: Long-Term Observation of Different Interval Growth.
Article in Heart, lung & circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The infiltration risk prediction models by logistic regression for ground-glass pulmonary nodules: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Clinical and CT Features of Subsolid Pulmonary Nodules With Interval Growth: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2022Pooled it
- Trajectories of pulmonary subsolid nodules in children and adolescents: a retrospective multicenter cohort study.European radiology · 2026Article
- Application and Development of Spectral CT in Target Delineation for Lung Cancer Radiotherapy.Diagnostics (Basel, Switzerland) · 2026Review
- Natural history and clinical characteristics of pulmonary subsolid nodules in pediatric patients: a cohort study.Quantitative imaging in medicine and surgery · 2026Article
- East-West Disparities in Lung Cancer Screening: Subsolid Nodule Prevalence, Interval Growth, and Decision-Making Analysis.Diagnostics (Basel, Switzerland) · 2026Review
- The role of growth heterogeneity in solid nodular non-small cell lung cancer in clinical practice: a narrative review.Journal of thoracic disease · 2026Review
- Utility and Safety of Endosonography in the Diagnosis of Small Cell Lung Cancer: A Prospective Single-Center Observational Study.Diagnostics (Basel, Switzerland) · 2026Article
- Incidental pulmonary findings on CT in daily practice: the nodule and the interstitial lung abnormalities - what's old, what's new.La Radiologia medica · 2026Review
- Correlation analysis between growth heterogeneity and genetic mutations in resected subsolid lung adenocarcinoma based on long-term computed tomography (CT) follow-up.Translational lung cancer research · 2026Article
- Management of suspicious nodules in lung cancer screening - a narrative review of monitoring strategies based on nodule features and further needs.Frontiers in oncology · 2026Review
- Correlation between CT growth patterns and invasiveness progression in neoplastic subcentimeter sub-solid nodules.Annals of medicine · 2025Article
- Understanding East-West differences in subsolid nodules: prevalence and overdiagnosis implications in lung cancer screening.Annals of medicine · 2025Article
- Prediction model for growth trends of subpleural subsolid nodules using CT radiomics and radiological features.Scientific reports · 2025Article
- Development and validation of growth prediction models for multiple pulmonary ground-glass nodules based on CT features, radiomics, and deep learning.Translational lung cancer research · 2025Article
- Natural course of lung adenocarcinoma manifesting as ground-glass nodules: invasiveness assessment based on growth evaluation.Translational lung cancer research · 2025Article
- Screening for Lung Cancer, Overdiagnosis, and Healthcare Utilization: A Nationwide Population-Based Study.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025Article
- The curative effect analysis of simultaneous U-VATS for bilateral multiple primary early-stage lung cancers.Frontiers in oncology · 2025Article
- Predicting EGFR gene mutation in lung adenocarcinoma using spectral CT combined with AI parameters: a diagnostic accuracy study.Frontiers in oncology · 2025Article
- Protocol for a single-arm, multicenter, prospective, confirmatory phase III trial of wedge resection for invasive ground glass opacity-featured lung cancer with a size ≤2 cm and a consolidation tumor ratio between 0.25 and 0.5 (ECTOP-1020 study).Journal of thoracic disease · 2024Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe long-term natural course and outcomes of subsolid nodules (SSNs) in terms of true growth, substantial growth, and stage shift need to be clarified.
methodsBetween 2002 and 2016, 128 subjects with persistent SSNs of 3cm or smaller were enrolled. The baseline and interval changes in the series computed tomography (CT) findings during the follow-up period were subsequently reviewed.
resultsThe mean follow-up period was 3.57±2.93years. The cumulative percentage of growth nodules of the part-solid nodule (PSN) group was significantly higher than that of the ground-glass nodule (GGN) group by Kaplan-Meier estimation (all p<0.0001). For true SSN growth, GGNs usually take a median follow-up of 7 years to grow; PSNs usually take a median follow-up of 3 years to grow. For substantial SSN growth, GGNs usually take a median follow-up of 9 years to grow; PSNs usually take a median follow-up of 3 years to grow. For stage shift, GGNs usually take a median follow-up of 12 years to grow; PSNs usually take a median follow-up of 9 years to grow.
conclusionsThe natural course in terms of true growth, substantial growth, and stage shift differed significantly according to their nodule type, which could contribute to the development of follow-up guidelines and management strategy of pulmonary SSNs.
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