ArticleCritical care (London, England)2018
A complete and multifaceted overview of antibiotic use and infection diagnosis in the intensive care unit: results from a prospective four-year registration.
Article in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of studies investigating ventilator associated pneumonia diagnostics in intensive care.BMC pulmonary medicine · 2021Pooled it
- Escalating Use of Antimicrobial Agents in Tertiary Hospitals: A Balancing Act in Preventing Hospital-Acquired infections.JNMA; journal of the Nepal Medical Association · 2025Article
- Antibiotic Use, Healthcare-Associated Infections, and Antimicrobial Resistance in Intensive Care Unit of a Serbian Tertiary University Hospital, 2018-2024: An Ecological Analysis.Antibiotics (Basel, Switzerland) · 2025Article
- Utilization of Antimicrobial Agents in Intensive Care Units of Tertiary Care Hospital: An Observational Study.JNMA; journal of the Nepal Medical Association · 2025Observational
- Antibiotic Utilization and Resistance According to the WHO AWaRe Classification in Intensive Care Units After COVID-19 Third Wave in Pakistan: Findings and Implications.Medicina (Kaunas, Lithuania) · 2025Article
- Diagnostic Performance and Impact on Antimicrobial Treatment of a Multiplex Polymerase Chain Reaction in Critically Ill Patients With Pneumonia: A Multicenter Observational Study (The MORICUP-PCR Study: Morocco ICU Pneumonia-PCR study).Critical care explorations · 2025Observational
- Reduced antimicrobial consumption through enhanced pneumonia management in critically ill patients: outcomes of an antibiotic stewardship program in the intensive care unit.Frontiers in medicine · 2025Article
- Performance and impact of rapid multiplex PCR on diagnosis and treatment of ventilated hospital-acquired pneumonia in patients with extended-spectrum β-lactamase-producing Enterobacterales rectal carriage.Annals of intensive care · 2024Article
- Automated surveillance of antimicrobial consumption in intensive care, northern Sweden: an observational case study.Antimicrobial resistance and infection control · 2024Observational
- The use of information technology to improve interdisciplinary communication during infectious diseases ward rounds on the paediatric intensive care unit.Scientific reports · 2024Observational
- Healthcare providers consistently overestimate the diagnostic probability of ventilator-associated pneumonia.Infection control and hospital epidemiology · 2023Article
- Article
- Pathogen-based target attainment of optimized continuous infusion dosing regimens of piperacillin-tazobactam and meropenem in surgical ICU patients: a prospective single center observational study.Annals of intensive care · 2023Article
- Antibiotics use evaluation among hospitalized adult patients at Jimma Medical Center, southwestern Ethiopia: the way to pave for antimicrobial stewardship.Journal of pharmaceutical policy and practice · 2022Article
- Characteristics of Sepsis-2 septic shock patients failing to satisfy the Sepsis-3 septic shock definition: an analysis of real-time collected data.Annals of intensive care · 2021Article
- The Utility of Bedside Assessment Tools and Associated Factors to Avoid Antibiotic Overuse in an Urban PICU of a Diarrheal Disease Hospital in Bangladesh.Antibiotics (Basel, Switzerland) · 2021Article
- A mandatory indication-registration tool in hospital electronic medical records enabling systematic evaluation and benchmarking of the quality of antimicrobial use: a feasibility study.Antimicrobial resistance and infection control · 2021Article
- Attributable Mortality of Ventilator-associated Pneumonia. Replicating Findings, Revisiting Methods.Annals of the American Thoracic Society · 2021Article
- Antibiotic utilization, sensitivity, and cost in the medical intensive care unit of a tertiary care teaching hospital in Nepal.SAGE open medicine · 2021Article
- Drug utilisation in adult, paediatric and neonatal intensive care units, with an emphasis on systemic antimicrobials.Anaesthesiology intensive therapy · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundPreparing an antibiotic stewardship program requires detailed information on overall antibiotic use, prescription indication and ecology. However, longitudinal data of this kind are scarce. Computerization of the patient chart has offered the potential to collect complete data of high resolution. To gain insight in our global antibiotic use, we aimed to explore antibiotic prescription in our intensive care unit (ICU) from various angles over a prolonged time period.
methodsWe studied all adult patients admitted to Ghent University Hospital ICU from 1 January 2013 until 31 December 2016. Antibiotic prescription data were prospectively merged with diagnostic (suspected focus, severity and probability of infection at the time of prescription, or prophylaxis) and microbiology data by ICU physicians during daily workflow through dedicated software. Definite focus of infection and probability of infection (classified as high/moderate/low) were reassessed by dedicated ICU physicians at patient discharge.
resultsDuring the study period, 8763 patients were admitted and overall antibiotic consumption amounted to 1232 days of therapy (DOT)/1000 patient days. Antibacterial DOT (84% of total DOT) were linked with infection in 80%; the predominant foci were the respiratory tract (49%) and the abdomen (19%). A microbial cause was identified in 56% (3169/5686). Moderate/low probability infections accounted for 42% of antibacterial DOT prescribed for respiratory tract infections; for abdominal infections, this figure was 15%. The median treatment duration of moderate/low probability respiratory infections was 4 days (IQR 3-7). Antifungal DOT (16% of total DOT) were linked with infection in 47% of total antifungal DOT. Antifungal prophylaxis was primarily administered in the surgical ICU (76%), with a median duration of 4 DOT (IQR 2-9).
conclusionsBy prospectively combining antibiotic, microbiology and clinical data we were able to construct a longitudinal, multifaceted dataset on antibiotic use and infection diagnosis. A complete overview of this kind may allow the identification of antibiotic prescription patterns that require future antibiotic stewardship attention.
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