ArticleNeuroImage. Clinical2018
Distinctive tics suppression network in Gilles de la Tourette syndrome distinguished from suppression of natural urges using multimodal imaging.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Structural and functional alterations in the brain gray matter among Tourette syndrome patients: a multimodal meta-analysis of fMRI and VBM studies.Journal of neurology · 2025Pooled it
- Target-Specific Effects of Deep Brain Stimulation for Tourette Syndrome: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome.Psychological medicine · 2023Trial
- Parietal signatures of urge control in paediatric tic disorders: Hyperactivation and salience-biased coupling.European child & adolescent psychiatry · 2026Article
- Brain-heart coupling in tourette syndrome: a precision functional mapping study of discordant siblings.Frontiers in network physiology · 2026Article
- Functional Neuroanatomy of Tics: A Brain Network Perspective.The Psychiatric clinics of North America · 2025Review
- EEG power modulation in the sensorimotor regions is critical to motor tic suppression.Frontiers in psychiatry · 2025Article
- The role of neuroactive steroids in tic disorders.Neuroscience and biobehavioral reviews · 2024Review
- Allopregnanolone: The missing link to explain the effects of stress on tic exacerbation?Journal of neuroendocrinology · 2022Review
- EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic Disorder.Brain sciences · 2022Article
- Towards real-world generalizability of a circuit for action-stopping.Nature reviews. Neuroscience · 2021Review
- Correlates and clinical implications of tic suppressibility.Current developmental disorders reports · 2021Article
- Frequency-Specific Regional Homogeneity Alterations in Tourette Syndrome.Frontiers in psychiatry · 2020Article
- Amplified engagement of prefrontal cortex during control of voluntary action in Tourette syndrome.Brain communications · 2020Article
- Modulation of Frontal Oscillatory Power during Blink Suppression in Children: Effects of Premonitory Urge and Reward.Cerebral cortex communications · 2020Article
- Non-invasive Brain Stimulation for the Treatment of Gilles de la Tourette Syndrome.Frontiers in neurology · 2020Review
- The urge to blink in Tourette syndrome.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Tourette syndrome research highlights from 2018.F1000Research · 2019Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesGilles de la Tourette syndrome (GTS) is a neuropsychiatric disorder characterized by tics. A hallmark of GTS is the ability to voluntarily suppress tics. Our aim was to distinguish the neural circuits involved in the voluntary suppression of ocular tics in GTS patients from blink suppression in healthy subjects.
methodsFifteen GTS patients and 22 healthy control subjects were included in a multimodal study using eye-tracker recordings during functional MRI (fMRI). The ability to suppress tics/blinks was compared both on subjective (self-rating) and objective (eye-tracker) performance. For fMRI analysis we used a novel designed performance-adapted block design analysis of tic/blink suppression and release based on eye-tracker monitoring.
resultsWe found that the subjective self-reported ability to suppress tics or blinks showed no significant correlation with objective task performance. In GTS during successful suppression of tics, the dorsal anterior cingulate cortex and associated limbic areas showed increased activation. During successful suppression of eye blinks in healthy subjects, the right ventrolateral prefrontal cortex and supplementary and cingulate motor areas showed increased activation.
conclusionsThese findings demonstrate that GTS patients use a characteristic limbic suppression strategy. In contrast, control subjects use the voluntary sensorimotor circuits and the classical 'stop' network to suppress natural urges. The employment of different neural suppression networks provides support for cognitive behavioral therapy in GTS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.