Trial reportThe journal of allergy and clinical immunology. In practice2019
Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation.
Trial report in The journal of allergy and clinical immunology. In practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06603584 (Phenotypes of Preschool Wheezing Among Children Attending Sohag University Hospital), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phenotypes of Preschool Wheezing Among Children Attending Sohag University Hospital
Who cites it
27 citing papers in PubMed.
- Improving asthma control assessment and outcomes in children with asthma using an artificial intelligence digital tool: a prospective multicentre cohort study.ERJ open research · 2026Article
- Improving the management and outcomes of preschool wheeze: protocol of a prospective multicentre cohort study.BMJ open respiratory research · 2026Article
- Clustering lung function and symptom profiles for asthma risk stratification.Scientific reports · 2025Article
- Recurrent Preschool Wheeze: The Impact of Adverse Social Drivers of Health and Opportunities for Interventions.The journal of allergy and clinical immunology. In practice · 2025Review
- Patterns of Respiratory Symptoms and Asthma Diagnosis in School-Age Children: Three Birth Cohorts.Allergy · 2025Article
- Characteristics of children with severe preschool asthma prior to starting the TIPP study.Frontiers in pediatrics · 2025Article
- Understanding and Managing Viral-Induced Wheezing in Children: The Role of Parental Knowledge.Journal of asthma and allergy · 2025Article
- Adult Outcomes of Childhood Wheezing Phenotypes Are Associated with Early-Life Factors.Journal of personalized medicine · 2024Article
- Emergency management and asthma risk in young Medicaid-enrolled children with recurrent wheeze.The Journal of asthma : official journal of the Association for the Care of Asthma · 2024Article
- Dysfunctional neutrophil type 1 interferon responses in preschool children with recurrent wheezing and IL-4-mediated aeroallergen sensitization.The journal of allergy and clinical immunology. Global · 2024Article
- Clinical Predictors of Severe Exacerbations in Pediatric Patients With Recurrent Wheezing.Cureus · 2024Article
- Artificial intelligence and wheezing in children: where are we now?Frontiers in medicine · 2024Review
- Functional immunophenotyping of blood neutrophils identifies novel endotypes of viral response in preschool children with recurrent wheezing.The Journal of allergy and clinical immunology · 2023Article
- Clinical features and later prognosis of replicable early-life wheeze clusters from two birth cohorts 12 years apart.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2023Article
- Social determinants of health influence preschool and caregiver experiences during symptoms and exacerbations of wheezing.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023Article
- Poorer Caregiver Mental and Social Health Is Associated With Worse Respiratory Outcomes in Preschool Children With Recurrent Wheezing.The journal of allergy and clinical immunology. In practice · 2023Article
- Blood Eosinophils for Prediction of Exacerbation in Preschool Children With Recurrent Wheezing.The journal of allergy and clinical immunology. In practice · 2023Article
- Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates.American journal of respiratory and critical care medicine · 2022Article
- Asthma and Allergy: Unravelling a Tangled Relationship with a Focus on New Biomarkers and Treatment.International journal of molecular sciences · 2022Review
- Atopic dermatitis and atopic march: which link?Acta bio-medica : Atenei Parmensis · 2021Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
backgroundRecurrent preschool wheezing is a heterogeneous disorder with significant morbidity, yet little is known about phenotypic determinants and their impact on clinical outcomes.
objectiveLatent class analysis (LCA) was used to identify latent classes of recurrent preschool wheeze and their association with future exacerbations and inhaled corticosteroid (ICS) treatment response.
methodsData from 5 clinical trials of 1708 children aged 12 to 71 months with recurrent wheezing were merged. LCA was performed on 10 demographic, exposure, and sensitization variables to determine the optimal number of latent classes. The primary outcome was the annualized rate of wheezing exacerbations requiring systemic corticosteroids during the study intervention period; the secondary outcome was the time to first exacerbation. Exploratory analyses examined the effect of daily ICS treatment on exacerbation outcomes.
resultsFour latent classes of recurrent wheezing were identified; these were not distinguished by current symptoms or historical exacerbations but differed with regard to allergen sensitization and/or exposures. Annualized exacerbation rates (mean ± SEM/year) were 0.65 ± 0.06 for class 1 ("minimal sensitization"), 0.93 ± 0.10 for class 2 ("sensitization with indoor pet exposure"), 0.60 ± 0.07 for class 3 ("sensitization with tobacco smoke exposure"), and 0.81 ± 0.10 for class 4 ("multiple sensitization and eczema") (P < .001). In a research setting of high adherence, daily ICS treatment improved exacerbation rates in classes 2 and 4 but not the other groups.
conclusionsSensitization and exposure assessments are useful in the prediction of future exacerbation and may identify children most likely to respond favorably to daily ICS treatment.
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Registered trials
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