ArticlePapillomavirus research (Amsterdam, Netherlands)2019
Long-term survival and swallowing outcomes in advanced stage oropharyngeal squamous cell carcinomas.
Article in Papillomavirus research (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05144100 (Primary Surgery Vs Primary Chemoradiation for Oropharyngeal Cancer), which is not on this map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Primary Surgery Vs Primary Chemoradiation for Oropharyngeal Cancer (Scope Trial) - A Phase II/III Integrated Design Randomized Control Trial
Who cites it
12 citing papers in PubMed.
- Longitudinal Functional Outcomes After Transoral Robotic Surgery Versus Transoral Videolaryngoscopic Surgery for Oropharyngeal Cancer: A Retrospective Single-Center Study.Laryngoscope investigative otolaryngology · 2026Article
- Plant Bioactive Constituents and Their Potential Benefits in HPV-Positive Oropharyngeal Squamous Cell Carcinoma-A Narrative Review.Current issues in molecular biology · 2026Review
- Comparison of Quality of Life After Transoral Robotic and Transoral Videolaryngoscopic Surgeries for Head and Neck Cancer.Laryngoscope investigative otolaryngology · 2026Article
- Multicentre study of inoperable HPV-negative head and neck cancer: a persistent real-world challenge.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026Article
- Nutritional Outcomes in HPV-Associated Oropharyngeal Squamous Cell Carcinoma After Transoral Robotic Surgery.The Laryngoscope · 2025Article
- Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model, cellular platform, and clinical human data.Animal models and experimental medicine · 2023Review
- Surgical Treatment for Advanced Oropharyngeal Cancer: A Narrative Review.Medicina (Kaunas, Lithuania) · 2023Review
- Schlafen family member 11 indicates favorable prognosis of patients with head and neck cancer following platinum-based chemoradiotherapy.Frontiers in oncology · 2022Article
- Macrophages expressing TREM-1 are involved in the progression of HPV16-related oropharyngeal squamous cell carcinoma.Annals of medicine · 2021Article
- Epidemiological trends of head and neck Cancer survivors in Alberta: towards improved understanding of the burden of disease.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2020Article
- Association of human papillomavirus related squamous cell carcinomas of the oropharynx and cervix.Papillomavirus research (Amsterdam, Netherlands) · 2019Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a paucity of studies reporting long-term survival outcomes for HPV/p16 positive oropharyngeal squamous cell carcinoma (OPSCC). This study aims to compare long-term outcomes of advanced stage p16 positive and negative OPSCCs, treated by surgical and non-surgical modalities.
methodsOPSCC patients from 1998 to 2012 were identified through a prospectively collected cancer registry. P16 immunohistochemistry was used as a surrogate marker for HPV-OPSCC. Overall survival (OS) and aspiration free survival (AFS) comparisons were made between patients treated with chemoradiation (CRT) versus primary surgery and radiation/chemoradiation (S+RT/CRT) at 5, 10 and 15 years post-treatment.
resultsA total of 319 patients were included. P16 positive patients and non-smokers had significantly higher long-term (5, 10 and 15-year) OS. Smokers and p16 negative patients treated with S+RT/CRT had improved long-term OS compared to patients who received CRT. Smokers and p16 negative patients had lower long-term AFS. Multivariate analysis showed improved OS was associated with p16 positivity (HR 0.42, 0.28-0.61) and surgery (HR 0.47, 0.32-0.69), whereas lower OS was associated with ECOG ≥ 2 (HR 2.46, 1.61-3.77), smoking (HR 2.37, 1.41-3.99) and higher stage (HR 1.68, 1.05-2.68).
conclusionsIn smokers and p16-negative OPSCC patients, primary surgery may be associated with improved long-term survival and dysphagia-related outcomes.
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Registered trials
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