Evidence map›Paper›PMID 30267742›Full record

ReviewAdvanced drug delivery reviews2019

Therapeutic strategies for enhancing angiogenesis in wound healing.

Austin P Veith, Kayla Henderson, Adrianne Spencer, Andrew D Sligar, Aaron B Baker

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05853237 (Class iv Versus Class Iiib Laser Therapy on Median Sternotomy Healing After Coronary Artery Bypass Graft), which is not on this map. Cited by 412 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
412citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05853237 nacompletednot on this mapstarted 2021, after this paper: background citation

Class iv Versus Class Iiib Laser Therapy on Median Sternotomy Healing After Coronary Artery Bypass Graft: a Randomize Control Trail

TypeinterventionalSponsorHeidy F. AhmedRan2021 to 2023Enrolled45ConditionsWound, Wound Heal, Wound InfectionArmslaser therapy for wound management
3 · Its place in the literature

Who cites it

412 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Toxins turned into medicines: A systematic review of peptide animal-derived venom in wound treatments.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026
    Pooled it
  2. DoesFrontiers in pharmacology · 2026
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  3. Pooled it
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  5. [Biological characteristics of urine-derived stem cells duringZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
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352 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Austin P VeithDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA.
Kayla HendersonDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA.
Adrianne SpencerDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA.
Andrew D SligarDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA.
Aaron B BakerDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA; The Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, TX, USA; Institute for Biomaterials, Drug Delivery and Regenerative Medicine, University of Texas at Austin, Austin, TX, USA. Electronic address: abbaker1@gmail.com.

Funding

Mechanical Conditioning of Mesenchymal Stem Cells for Enhanced Recellularized Vascular GraftsR01HL141761 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI BAKER, AARON BLAIR · 2018 to 2021
$1.6M
Syndecan-1 in Mechanosensing of Engineered MicroenvironmentsR21EB023551 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI BAKER, AARON BLAIR · 2017 to 2018
$450k
Glycocalyx Mimetic Polysaccharides as Therapeutics for AtherosclerosisR21EB024147 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI BAKER, AARON BLAIR · 2017 to 2018
$430k
NHLBI NIH HHS R01 HL141761NIBIB NIH HHS R21 EB023551NIBIB NIH HHS R21 EB024147
6 · The paper itself

Abstract

The enhancement of wound healing has been a goal of medical practitioners for thousands of years. The development of chronic, non-healing wounds is a persistent medical problem that drives patient morbidity and increases healthcare costs. A key aspect of many non-healing wounds is the reduced presence of vessel growth through the process of angiogenesis. This review surveys the creation of new treatments for healing cutaneous wounds through therapeutic angiogenesis. In particular, we discuss the challenges and advancement that have been made in delivering biologic, pharmaceutical and cell-based therapies as enhancers of wound vascularity and healing.

Indexed as

Cell- and Tissue-Based TherapyWound HealingAnimalsDrug Delivery SystemsHumansNeovascularization, PathologicAngiogenesisCell-based therapiesChronic woundsDiabetic ulcersGrowth factor therapyNeovascularizationNon-healing woundsStem cell therapyWound healing

Identifiers

PMID30267742
PMCPMC6435442

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.