ArticleJournal of neuroscience methods2019
Cognitive tasks and human ambulatory electrocorticography using the RNS System.
Article in Journal of neuroscience methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Intracranial substrates of meditation-induced neuromodulation in the amygdala and hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Long-Term Ambulatory Intracranial EEG.Stereotactic and functional neurosurgery · 2025Review
- Mobile cognition: imaging the human brain in the 'real world'.Nature reviews. Neuroscience · 2023Review
- Large-scale, closed-loop interrogation of neural circuits underlying cognition.Trends in neurosciences · 2022Review
- Advances in human intracranial electroencephalography research, guidelines and good practices.NeuroImage · 2022Review
- Effects of anterior thalamic nuclei stimulation on hippocampal activity: Chronic recording in a patient with drug-resistant focal epilepsy.Epilepsy & behavior reports · 2021Article
- Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans.Neuron · 2020Article
- Functionally distinct high and low theta oscillations in the human hippocampus.Nature communications · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundElectrocorticography studies are typically conducted in patients undergoing video EEG monitoring, but these studies are subject to confounds such as the effects of pain, recent anesthesia, analgesics, drug changes, antibiotics, and implant effects. NEW
methodTechniques were developed to obtain electrocorticographic (ECoG) data from freely moving subjects performing navigational tasks using the RNS
resultsTask synchronization using the synchronization marker technique provides a quantitative measure of clock uncertainty, and can align data to task events with less than 4 ms of uncertainty. Hippocampal ECoG activity was found to change immediately before an incorrect response to a math problem compared to hippocampal activity before a correct response. In addition, subjects were found to have variable but significant changes in theta band power in the hippocampus during navigation compared to when subjects were not navigating. We found that there is theta-gamma phase-amplitude coupling in the right hippocampus while subjects stand still during a navigation task. COMPARISON WITH EXISTING
methodsAn alignment technique described in this study improves the upper bound on task-ECoG alignment uncertainty from approximately 30 ms to under 4 ms. The RNS System is one of the first platforms capable of providing untethered ambulatory ECoG recording in humans, allowing for the study of real world instead of virtual navigation. Compared to intracranial video EEG studies, studies using the RNS System platform are not subject to confounds caused by the drugs and recent surgery inherent to the perioperative environment. Furthermore, these subjects provide the opportunity to record from the same electrodes over the course of many years.
conclusionsThe RNS System enables us to study human navigation with unprecedented clarity. While RNS System patients have fewer electrodes implanted than video EEG patients, the lack of external artifact and confounds from recent surgery make this system a useful tool to further human electrophysiology research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.