Evidence map›Paper›PMID 30267679›Full record

ArticleiScience2018

A Membrane-Bound Biosensor Visualizes Shear Stress-Induced Inhomogeneous Alteration of Cell Membrane Tension.

Wang Li, Xinlei Yu, Fei Xie, Baohong Zhang, Shuai Shao, Chunyang Geng, Aziz Ur Rehman Aziz, Xiaoling Liao, Bo Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  15. Interplay between mechanics and signalling in regulating cell fate.Nature reviews. Molecular cell biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wang LiSchool of Biomedical Engineering, Dalian University of Technology, Liaoning IC Technology Key Lab, Dalian 116024, China.
Xinlei YuSchool of Biomedical Engineering, Dalian University of Technology, Liaoning IC Technology Key Lab, Dalian 116024, China.
Fei XieSchool of Biomedical Engineering, Dalian University of Technology, Liaoning IC Technology Key Lab, Dalian 116024, China.
Baohong ZhangSchool of Biomedical Engineering, Dalian University of Technology, Liaoning IC Technology Key Lab, Dalian 116024, China.
Shuai ShaoSchool of Biomedical Engineering, Dalian University of Technology, Liaoning IC Technology Key Lab, Dalian 116024, China.
Chunyang GengSchool of Biomedical Engineering, Dalian University of Technology, Liaoning IC Technology Key Lab, Dalian 116024, China.
Aziz Ur Rehman AzizSchool of Biomedical Engineering, Dalian University of Technology, Liaoning IC Technology Key Lab, Dalian 116024, China.
Xiaoling LiaoBiomaterials and Live Cell Imaging Institute, Chongqing University of Science and Technology, Chongqing 400030, China.
Bo LiuSchool of Biomedical Engineering, Dalian University of Technology, Liaoning IC Technology Key Lab, Dalian 116024, China. Electronic address: lbo@dlut.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell membrane is the first medium from where a cell senses and responds to external stress stimuli. Exploring the tension changes in cell membrane will help us to understand intracellular force transmission. Here, a biosensor (named MSS) based on fluorescence resonance energy transfer is developed to visualize cell membrane tension. Validity of the biosensor is first verified for the detection of cell membrane tension. Results show a shear stress-induced heterogeneous distribution of membrane tension with the biosensor, which is strengthened by the disruption of microfilaments or enhancement of membrane fluidity, but weakened by the reduction of membrane fluidity or disruption of microtubules. These findings suggest that the MSS biosensor is a beneficial tool to visualize the changes and distribution of cell membrane tension. Besides, cell membrane tension does not display obvious polar distribution, indicating that cellular polarity changes do not first occur on the cell membrane during mechanical transmission.

Indexed as

BiophysicsMembrane ArchitectureMolecular BiologySensor

Identifiers

PMID30267679
PMCPMC6153118

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.