Evidence map›Paper›PMID 30267675›Full record

ArticleiScience2018

Bottom-Up Evolution of Vesicles from Disks to High-Genus Polymersomes.

Claudia Contini, Russell Pearson, Linge Wang, Lea Messager, Jens Gaitzsch, Loris Rizzello, Lorena Ruiz-Perez, Giuseppe Battaglia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Thermally Driven Dynamic Behaviors in Polymeric Vesicles.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  3. Aqueous Self-Assembly of Cylindrical and Tapered Bottlebrush Block Copolymers.Angewandte Chemie (International ed. in English) · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Manufacturing polymeric porous capsules.Chemical communications (Cambridge, England) · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Claudia ContiniDepartment of Chemistry, University College London, 20 Gordon Street, Christopher Ingold Building, London WC1H 0AJ, UK; Department of Chemistry, Imperial College London, Imperial College Rd, London SW7 2AZ, UK.
Russell PearsonDepartment of Materials Science and Engineering, University of Sheffield, Broad Lane, Sheffield S3 7HQ, UK.
Linge WangDepartment of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK; South China Advanced Institute for Soft Matter Science and Technology, South China University of Technology, Guangzhou 510640, China.
Lea MessagerDepartment of Chemistry, University College London, 20 Gordon Street, Christopher Ingold Building, London WC1H 0AJ, UK; LAGEP, University Claude Bernard Lyon, 43 Boulevard du 11 Novembre 1918, Lyon 69622, France.
Jens GaitzschDepartment of Chemistry, University College London, 20 Gordon Street, Christopher Ingold Building, London WC1H 0AJ, UK; Department of Chemistry, University of Basel, Mattenstrasse 24a, BPR1096, Basel 4058, Switzerland.
Loris RizzelloDepartment of Chemistry, University College London, 20 Gordon Street, Christopher Ingold Building, London WC1H 0AJ, UK; Institute of Physics of Living System, University College London, 19 Gordon St, London WC1H 0AH, UK.
Lorena Ruiz-PerezDepartment of Chemistry, University College London, 20 Gordon Street, Christopher Ingold Building, London WC1H 0AJ, UK; EPSRC/Jeol Centre for Liquid Phase Electron Microscopy, University College London, 20 Gordon Street, London WC1H 0AJ, UK; Institute of Physics of Living System, University College London, 19 Gordon St, London WC1H 0AH, UK.
Giuseppe BattagliaDepartment of Chemistry, University College London, 20 Gordon Street, Christopher Ingold Building, London WC1H 0AJ, UK; EPSRC/Jeol Centre for Liquid Phase Electron Microscopy, University College London, 20 Gordon Street, London WC1H 0AJ, UK; Institute of Physics of Living System, University College London, 19 Gordon St, London WC1H 0AH, UK; Department of Chemical Engineering, University College London, Torrington Place, London WC1E 6BT, UK. Electronic address: g.battaglia@ucl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymersomes are vesicles formed by the self-assembly of amphiphilic copolymers in water. They represent one of the most promising alternatives of natural vesicles as they add new possibilities in the amphiphiles' molecular engineering of aqueous compartments. Here we report the design of polymersomes using a bottom-up approach wherein self-assembly of amphiphilic copolymers poly(2-(methacryloyloxy) ethyl phosphorylcholine)-poly(2-(diisopropylamino) ethyl methacrylate) (PMPC-PDPA) into membranes is tuned using pH and temperature. We report evolution from disk micelles, to vesicles, to high-genus vesicles (vesicles with many holes), where each passage is controlled by pH switch or temperature. We show that the process can be rationalized, adapting membrane physics theories to disclose scaling principles that allow the estimation of minimal radius of vesiculation as well as chain entanglement and coupling. This approach allows us to generate nanoscale vesicles with genus from 0 to 70, which have been very elusive and difficult to control so far.

Indexed as

ColloidsMaterials ChemistryPolymer Chemistry

Identifiers

PMID30267675
PMCPMC6153420

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.