ArticleHuman brain mapping2019
White matter alterations and tract lateralization in children with dyslexia and isolated spelling deficits.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Emerging technologies and neuroscience-based approaches in dyslexia: a narrative review toward integrative and personalized solutions.Frontiers in human neuroscience · 2025Pooled it
- Heritable and experience-dependent cortical traits of reading ability.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- White matter microstructural alterations correlate with clinical characteristics in craniocervical dystonia.Neuroradiology · 2026Article
- Lifespan Trajectories of Asymmetry in White Matter Tracts.Human brain mapping · 2026Article
- Tractometry-Based Quantification of Along-Tract White-Matter Hemispheric Asymmetry in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2026Article
- The Relation of the Home Literacy Environment to White Matter Pathways Associated with Language in Children 5-8 Years Old.Neurobiology of language (Cambridge, Mass.) · 2026Article
- The superficial white matter in language processing: Broca's area connections are bilaterally associated with individual performance in children and adults.bioRxiv : the preprint server for biology · 2025Article
- Reading and White Matter Development: A Systematic Review of Neuroplastic Changes in Literacy.Children (Basel, Switzerland) · 2025Review
- Toward a Mechanistic Understanding of Reading Difficulties: Deviant Audiovisual Learning Dynamics and Network Connectivity in Children with Poor Reading Skills.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Phonological decoding ability is associated with fiber density of the left arcuate fasciculus longitudinally across reading development.Developmental cognitive neuroscience · 2025Article
- Altered white matter connectivity is linked to language abilities in children with autism spectrum disorder: An automated fiber quantification study.Frontiers in psychiatry · 2025Article
- Impact of COVID-19 School Closures on White Matter Plasticity in the Reading Network.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Cerebello-Cerebral Pathways Contribute to Written Word Production.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Modeling dyslexia in neurotypical adults by combining neuroimaging and neuromodulation techniques: a hypothesis paper.Frontiers in human neuroscience · 2025Article
- No Support for White Matter Alterations in Adults With Dyslexia: A Fixel-Based Diffusion MRI Study.Neurobiology of language (Cambridge, Mass.) · 2025Article
- An examination of cortical thickness relationships within the reading network of adults.Brain structure & function · 2024Article
- White matter associations with spelling performance.Brain structure & function · 2024Article
- White matter microstructure damage measured by automated fiber quantification correlates with pain symptoms in lung cancer patients.Brain imaging and behavior · 2024Article
- Cross-sectional and longitudinal evaluation of white matter microstructure damage and cognitive correlations by automated fibre quantification in relapsing-remitting multiple sclerosis patients.Brain imaging and behavior · 2024Article
- Investigating Dyslexia through Diffusion Tensor Imaging across Ages: A Systematic Review.Brain sciences · 2024Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The present study investigated whether children with a typical dyslexia profile and children with isolated spelling deficits show a distinct pattern of white matter alteration compared with typically developing peers. Relevant studies on the topic are scarce, rely on small samples, and often suffer from the limitations of conventional tensor-based methods. The present Constrained Spherical Deconvolution study includes 27 children with typical reading and spelling skills, 21 children with dyslexia and 21 children with isolated spelling deficits. Group differences along major white matter tracts were quantified utilizing the Automated Fiber Quantification software and a lateralization index was calculated in order to investigate the structural asymmetry of the tracts. The two deficit groups mostly displayed different patterns of white matter alterations, located in the bilateral inferior longitudinal fasciculi, right superior longitudinal fasciculus, and cingulum for the group with dyslexia and in the left arcuate fasciculus for the group with isolated spelling deficits. The two deficit groups differed also with respect to structural asymmetry. Children with dyslexia did not show the typical leftward asymmetry of the arcuate fasciculus, whereas the group with isolated spelling deficits showed absent rightward asymmetry of the inferior fronto-occipital fasciculus. This study adds evidence to the notion that different profiles of combined or isolated reading and spelling deficits are associated with different neural signatures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.