Evidence map›Paper›PMID 30267614›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2018

Using clinical and genetic data to predict pulmonary hypertension in bronchopulmonary dysplasia.

J K Trittmann, A Bartenschlag, E J Zmuda, J Frick, W C L Stewart, L D Nelin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

J K TrittmannPulmonary Hypertension Group, Center for Perinatal Research, The Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0002-3932-9204
A BartenschlagPulmonary Hypertension Group, Center for Perinatal Research, The Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
E J ZmudaDepartment of Pediatrics, The Ohio State University, Columbus, OH, USA.ORCID 0000-0001-9832-3147
J FrickInstitute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
W C L StewartDepartment of Pediatrics, The Ohio State University, Columbus, OH, USA.
L D NelinPulmonary Hypertension Group, Center for Perinatal Research, The Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0002-3722-3035
Nationwide Children's Hospital · USBattelle · US

Funding

The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
Novel therapeutic targets for bronchopulmonary dysplasia-associated pulmonary hypertensionK08HL129080 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI TRITTMANN, JENNIFER K · 2016 to 2020
$768k
NHLBI NIH HHS K08 HL129080
6 · The paper itself

Abstract

aimPulmonary hypertension significantly increases morbidity and mortality in infants with bronchopulmonary dysplasia. The frequency of single nucleotide polymorphisms in arginase-1 (ARG1 rs2781666) and dimethylarginine dimethylaminohydrolase-1 (DDAH1 rs480414) genes has been found to differ in a cohort of bronchopulmonary dysplasia patients with pulmonary hypertension (cases) and without pulmonary hypertension (controls). Therefore, we tested the hypothesis that combining these genotypes with phenotypic data would better predict pulmonary hypertension in bronchopulmonary dysplasia patients.

methodsBronchopulmonary dysplasia patients (n = 79) born at <35 weeks gestation were studied. Pulmonary hypertension was diagnosed by echocardiographic criteria (n = 20). ROC curves to predict pulmonary hypertension in bronchopulmonary dysplasia were generated from genotype and/or clinical data.

resultsCases were born at an earlier gestation and weighed less at birth than did controls. ROC curves for rs2781666 had an AUC of 0.61, while rs480414 had an AUC of 0.66. Together, the AUC was 0.70. When clinical data were added to the genetic model, AUC was 0.73.

conclusionThese findings demonstrate that ROC predictive modelling of pulmonary hypertension in bronchopulmonary dysplasia improves with inclusion of both genotypic and phenotypic data. Further refinement of these types of models could facilitate the implementation of precision medicine approaches to pulmonary hypertension in bronchopulmonary dysplasia.

Indexed as

AmidohydrolasesArginaseBronchopulmonary DysplasiaCase-Control StudiesHumansHypertension, PulmonaryInfant, NewbornInfant, PrematureROC CurveAmidohydrolasesARG1 protein, humanArginasedimethylargininaseArginaseDimethylarginine dimethylaminohydrolaseNeonatologyPredictive modelPrematurity

Identifiers

PMID30267614
PMCPMC6226353
OpenAlexW2892988851

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.