ArticleThe Journal of physiology2018
Renal reactivity: acid-base compensation during incremental ascent to high altitude.
Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Partial Pressure of Arterial Oxygen in Healthy Adults at High Altitudes: A Systematic Review and Meta-Analysis.JAMA network open · 2023Pooled it
- Renal Physiological Adaptation to High Altitude: A Systematic Review.Frontiers in physiology · 2020Pooled it
- Effects of the micronutrient Sanopal® (5-hydroxymethyl-2-furfural and α-ketoglutaric acid) on oxygen affinity of hemoglobin, oxygen saturation and exercise responses at altitude.Journal of the International Society of Sports Nutrition · 2026Trial
- Effect of Carbohydrate-Electrolyte Solution Including Bicarbonate Ion Ad Libitum Ingestion on Urine Bicarbonate Retention during Mountain Trekking: A Randomized, Controlled Pilot Study.International journal of environmental research and public health · 2021Trial
- Effect of chronic high-altitude exposure on postoperative pulmonary complications: a retrospective cohort study.Annals of medicine · 2026Article
- Intermittent hypoxia interventions for inducing ventilatory acclimatization to high altitude?Experimental physiology · 2026Review
- Altitude-Related Laboratory Changes and a Novel Hemoglobin Estimation Model: A Retrospective Analysis in Children and Adults.International journal of laboratory hematology · 2026Article
- Resting pulsatile cerebrovascular hemodynamics in people with Down syndrome.European journal of applied physiology · 2026Article
- Biomarkers and potential subtypes of acute mountain sickness: A state-of-the-science review.Redox biology · 2026Review
- Interactions between kidney proteins and metabolism in Tibetan sheep at different altitudes.BMC genomics · 2026Article
- Cardiovascular Exercise Physiology Under Hypoxia, Microgravity, and Heat Stress: A Review with Public Health Implications.International journal of environmental research and public health · 2026Review
- Time course of acid-base regulation at high-altitude: A century of insight.Experimental physiology · 2026Article
- Early acclimatization to high altitude: Acid-base and fluid balance dynamics during the first 2 days at 3100 m.Experimental physiology · 2026Article
- Response to the letter from Bushfield and Day: Potential pitfalls of using a correction to normative values in the assessment of acid-base compensation during early ascent to high altitude.Experimental physiology · 2026Article
- Potential pitfalls of using a correction to normative values for the assessment of acid-base compensation during early ascent to high altitude.Experimental physiology · 2026Article
- Characterizing the protective vasodilatory effects of hypobaric hypoxia on the neurovascular coupling response.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Preacclimatization and base excess rather than deficit?Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reply to Kleinsasser et al.: Superimposed acclimatization and adaptation to low and high altitudes in highlanders compared to lowlanders.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparing integrative ventilatory and renal acid-base acclimatization in lowlanders and Tibetan highlanders during ascent to 4,300 m.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Research on related factors of hyperuricemia in high altitude area migrant population.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
Abstract
key pointsAscent to high altitude imposes an acid-base challenge in which renal compensation is integral for maintaining pH homeostasis, facilitating acclimatization and helping prevent mountain sicknesses. The time-course and extent of plasticity of this important renal response during incremental ascent to altitude is unclear. We created a novel index that accurately quantifies renal acid-base compensation, which may have laboratory, fieldwork and clinical applications. Using this index, we found that renal compensation increased and plateaued after 5 days of incremental altitude exposure, suggesting plasticity in renal acid-base compensation mechanisms. The time-course and extent of plasticity in renal responsiveness may predict severity of altitude illness or acclimatization at higher or more prolonged stays at altitude. ABSTRACT: Ascent to high altitude, and the associated hypoxic ventilatory response, imposes an acid-base challenge, namely chronic hypocapnia and respiratory alkalosis. The kidneys impart a relative compensatory metabolic acidosis through the elimination of bicarbonate (HCO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.