Evidence map›Paper›PMID 30267369›Full record

ReviewProgress in biomaterials2018

The role of stem cell therapy in regeneration of dentine-pulp complex: a systematic review.

Hengameh Bakhtiar, Amir Mazidi S, Saeed Mohammadi Asl, M R Ellini, A Moshiri, M H Nekoofar, P M H Dummer

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Regenerative Endodontic Procedures: An Umbrella Review.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Hengameh BakhtiarEndodontic Department, Dental Material Research Center, Tehran Dental Branch, Islamic Azad University, Tehran, Iran. hengamehbakhtiar@gmail.com.ORCID http://orcid.org/0000-0002-5847-5522
Amir Mazidi SStudent Research Committee, Islamic Azad University, Tehran branch, No. 4, 10th Neyestan St., Pasdaran Ave, Tehran, Iran.
Saeed Mohammadi AslStudent Research Committee, Islamic Azad University, Tehran branch, No. 4, 10th Neyestan St., Pasdaran Ave, Tehran, Iran.
M R ElliniEndodontic Department, Dental Material Research Center, Tehran Dental Branch, Islamic Azad University, Tehran, Iran.
A MoshiriDepartment of Orthopedic Surgery, School of Medicine, AJA University of Medical Science, West Fatemi St, Etemadzadeh St, Tehran, Iran.
M H NekoofarDepartment of Endodontics, School of Dentistry, Tehran University of Medical Sciences, North Karegar St, P.O. Box: 14395-433, Tehran, 14399-55991, Iran.
P M H DummerEndodontology Research Group, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff, CF14 4XY, UK.
Islamic Azad University, Tehran · IRAja University of Medical Sciences · IRCardiff University · GBIslamic Azad University Dental Branch of Tehran · IRTehran University of Medical Sciences · IR

Funding

National Institute for Medical Research Develompent 950738
6 · The paper itself

Abstract

Infection of the dental pulp will result in inflammation and eventually tissue necrosis which is treated conventionally by pulpectomy and root canal treatment. Advances in regenerative medicine and tissue engineering along with the introduction of new sources of stem cells have led to the possibility of pulp tissue regeneration. This systematic review analyzes animal studies published since 2010 to determine the ability of stem cell therapy to regenerate the dentine-pulp complex (DPC) and the success of clinical protocols. In vitro and human clinical studies are excluded and only the experimental studies on animal models were included. Dental pulp stem cells constitute the most commonly used cell type. The majority of stem cells are incorporated into various types of scaffold and implanted into root canals. Some of the studies combine growth factors with stem cells in an attempt to improve the outcome. Studies of ectopic transplantation using small animal models are simple and non-systematic evaluation techniques. Stem cell concentrations have not been so far reported; therefore, the translational value of such animal studies remains questionable. Though all types of stem cells appear capable of regenerating a dentine-pulp complex, still several factors have been considered in selecting the cell type. Co-administrative factors are essential for inducing the systemic migration of stem cells, and their vascularization and differentiation into odontoblast-like cells. Scaffolds provide a biodegradable structure able to control the release of growth factors. To identify problems and reduce costs, novel strategies should be initially tested in subcutaneous or renal capsule implantation followed by root canal models to confirm results.

Indexed as

DentinogenesisDentin-pulp complexRegenerative medicineStem cell therapyTissue engineering

Identifiers

PMID30267369
PMCPMC6304177
OpenAlexW2892483085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.