ArticleJournal of chemical ecology2019
An IDS-Type Sesquiterpene Synthase Produces the Pheromone Precursor (Z)-α-Bisabolene in Nezara viridula.
Article in Journal of chemical ecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Expansion of the geranylgeranyl pyrophosphate synthase gene family underlies the evolution of terpenoid biosynthesis in termites.PLoS biology · 2026Article
- Natural Products from Soft Corals in Taiwan: Insights into Chemical Taxonomy and Potential Interaction in Marine Environments.Marine biotechnology (New York, N.Y.) · 2025Review
- Success of parasitism of Nezara viridula and Halyomorpha halys (Hemiptera: Pentatomidae) by Trichopoda pennipes (Diptera: Tachinidae) in the southeastern United States.Journal of insect science (Online) · 2025Article
- A diterpene synthase from the sandflyProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Emergence of terpene chemical communication in insects: Evolutionary recruitment of isoprenoid metabolism.Protein science : a publication of the Protein Society · 2023Article
- Genome mining of cryptic bisabolenes that were biosynthesized by intramembrane terpene synthases fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Article
- Differential gene expression underlying the biosynthesis of Dufour's gland signals inCurrent research in insect science · 2023Article
- Phytochemical Profile, Preliminary Toxicity, and Antioxidant Capacity of the Essential Oils ofAntioxidants (Basel, Switzerland) · 2022Article
- Biosynthesis of iridoid sex pheromones in aphids.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- A novel terpene synthase controls differences in anti-aphrodisiac pheromone production between closely related Heliconius butterflies.PLoS biology · 2021Article
- Evolution of isoprenyl diphosphate synthase-like terpene synthases in fungi.Scientific reports · 2020Article
- Linking Genes to Molecules in Eukaryotic Sources: An Endeavor to Expand Our Biosynthetic Repertoire.Molecules (Basel, Switzerland) · 2020Review
- The biosynthetic diversity of the animal world.The Journal of biological chemistry · 2019Review
- A Comprehensive Survey on the Terpene Synthase Gene Family Provides New Insight into Its Evolutionary Patterns.Genome biology and evolution · 2019Article
- Isoprenyl diphosphate synthases: the chain length determining step in terpene biosynthesis.Planta · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Insects use a wide range of structurally diverse pheromones for intra-specific communication. Compounds in the class of terpenes are emitted as sex, aggregation, alarm, or trail pheromones. Despite the common occurrence of terpene pheromones in different insect lineages, their origin from dietary host plant precursors or de novo biosynthetic pathways often remains unknown. Several stink bugs (Hemiptera: Pentatomidae) release bisabolene-type sesquiterpenes for aggregation and mating. Here we provide evidence for de novo biosynthesis of the sex pheromone trans-/cis-(Z)-α-bisabolene epoxide of the Southern green stink bug, Nezara viridula. We show that an enzyme (NvTPS) related to isoprenyl diphosphate synthases (IDSs) of the core terpene metabolic pathway functions as a terpene synthase (TPS), which converts the general intermediate (E,E)-farnesyl diphosphate (FPP) to the putative pheromone precursor (+)-(S,Z)-α-bisabolene in vitro and in protein lysates. A second identified IDS-type protein (NvFPPS) makes the TPS substrate (E,E)-FPP and functions as a bona fide FPP synthase. NvTPS is highly expressed in male epidermal tissue associated with the cuticle of ventral sternites, which is in agreement with the male specific release of the pheromone from glandular cells in this tissue. Our study supports findings of the function of similar TPS enzymes in the biosynthesis of aggregation pheromones from the pine engraver beetle Ips pini, the striped flea beetle Phyllotreta striolata, and the harlequin bug Murgantia histrionica, and hence provides growing evidence for the evolution of terpene de novo biosynthesis by IDS-type TPS families in insects.
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