Evidence map›Paper›PMID 30267337›Full record

ReviewBiophysical reviews2018

Epigenetic influences on genetically triggered thoracic aortic aneurysm.

Stefanie S Portelli, Elizabeth N Robertson, Cassandra Malecki, Kiersten A Liddy, Brett D Hambly, Richmond W Jeremy

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biophysical reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Stefanie S PortelliDiscipline of Pathology and Bosch Institute, The University of Sydney, Sydney, NSW, 2006, Australia. stefanie.portelli@sydney.edu.au.ORCID http://orcid.org/0000-0002-7139-6626
Elizabeth N RobertsonDiscipline of Pathology and Bosch Institute, The University of Sydney, Sydney, NSW, 2006, Australia.
Cassandra MaleckiDiscipline of Pathology and Bosch Institute, The University of Sydney, Sydney, NSW, 2006, Australia.
Kiersten A LiddyDiscipline of Pathology and Bosch Institute, The University of Sydney, Sydney, NSW, 2006, Australia.
Brett D HamblyDiscipline of Pathology and Bosch Institute, The University of Sydney, Sydney, NSW, 2006, Australia.
Richmond W JeremyDiscipline of Pathology and Bosch Institute, The University of Sydney, Sydney, NSW, 2006, Australia.
The University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetically triggered thoracic aortic aneurysms (TAAs) account for 30% of all TAAs and can result in early morbidity and mortality in affected individuals. Epigenetic factors are now recognised to influence the phenotype of many genetically triggered conditions and have become an area of interest because of the potential for therapeutic manipulation. Major epigenetic modulators include DNA methylation, histone modification and non-coding RNA. This review examines epigenetic modulators that have been significantly associated with genetically triggered TAAs and their potential utility for translation to clinical practice.

Indexed as

Aortic dilatationEpigeneticsMicroRNANon-coding RNAThoracic aortic aneurysm

Identifiers

PMID30267337
PMCPMC6233334
OpenAlexW2893227259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.