ArticleWorld journal of urology2019
Treatment utilization and overall survival in patients receiving radical nephroureterectomy versus endoscopic management for upper tract urothelial carcinoma: evaluation of updated treatment guidelines.
Article in World journal of urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Endoscopic intervention versus radical nephroureterectomy for the management of localized upper urinary tract urothelial carcinoma: a systematic review and meta-analysis of comparative studies.World journal of urology · 2024Pooled it
- Pharmacokinetics of UGN-101, a mitomycin-containing reverse thermal gel instilled via retrograde catheter for the treatment of low-grade upper tract urothelial carcinoma.Cancer chemotherapy and pharmacology · 2021Trial
- The Influence of Age on Cancer-Specific and Other-Cause Mortality in Upper Tract Urothelial Carcinoma.Cancers · 2026Article
- Radical Nephroureterectomy Pentafecta as a Predictor of Upper Tract Urothelial Carcinoma Outcomes Following Radical Surgery.Annals of surgical oncology · 2026Article
- Endoscopic ablation versus nephroureterectomy in localized low-grade upper tract urothelial carcinoma: a comparison in terms of cancer-specific and other-cause mortality.World journal of urology · 2025Article
- Minimally Invasive One-Docking, Two-Target, and Three-Port Robotic-Assisted Nephroureterectomy: Redefining Surgical Approach.Cancers · 2025Article
- [Functional and oncologic outcomes of partial nephrectomy for cystic renal cell carcinoma: A single-center retrospective study].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Development and Validation of a Preoperative Nomogram for Endoscopic Management Decision Making in Upper Urinary Tract Urothelial Carcinoma.Annals of surgical oncology · 2024Article
- Advances in chemoablation in upper tract urothelial carcinoma: overview of indications and treatment patterns.Translational andrology and urology · 2023Review
- Outcome of Non-Muscle Invasive Upper Tract Urothelial Carcinoma Receiving Endoscopic Ablation: An Inverse Probability of Treatment Weighting Analysis.Journal of clinical medicine · 2022Article
- Retroperitoneoscopic proximal ureter resection and ureteroureterostomy as an alternative management for upper tract urothelial carcinoma: A case report.Urology case reports · 2022Article
- Treatment Patterns, Outcomes, and Costs Associated With Localized Upper Tract Urothelial Carcinoma.JNCI cancer spectrum · 2021Article
- Role of Ureteroscopy in Treatment of Upper Tract Urothelial Carcinoma.Current urology reports · 2021Review
- Adjuvant and ablative therapies for low-risk UTUC: avenues to enhance kidney preservation.Nature reviews. Urology · 2020Article
- Management of Low-grade Upper Tract Urothelial Carcinoma: An Unmet Need.Reviews in urology · 2020Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
purposeWhile radical nephroureterectomy (RNU) is the gold standard treatment for upper tract urothelial carcinoma (UTUC), select patients may benefit from endoscopic treatment (ET). European Association of Urology guidelines recommend ET for patients with low-risk (LR) disease: unifocal, < 2 cm, low-grade lesions without local invasion. To inform the utility of ET, we compare the overall survival (OS) of patients receiving ET and RNU using current and previous guidelines of LR disease. MATERIALS AND
methodsPatients with non-metastatic, cT1 or less UTUC diagnosed in 2004-2012 were collected from the National Cancer Database. OS was analyzed with inverse probability of treatment weighted Cox proportional hazard regression. Analyses were conducted for LR disease under updated (size < 2 cm) and previous guidelines (size < 1 cm).
resultsPatients who were older, healthier, and treated at an academic facility had higher odds of receiving ET. In 851 identified patients with LR disease, RNU was associated with increased OS compared with ET (p = 0.006); however, there was no difference between ET and RNU (p = 0.79, n = 202) under the previous guidelines (size < 1 cm). In, otherwise, LR patients, the largest tumor size with no difference between ET and RNU was ≤ 1.5 cm (p = 0.07).
conclusionsRNU is associated with improved survival when compared with ET in the management of LR UTUC using current guidelines with a size threshold of < 2 cm. In appropriately selected LR patients, we find no difference between RNU and ET up to a tumor size of ≤ 1.5 cm. However, in the absence of prospective studies, the usage of ET is best left up to clinician discretion.
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