ArticlePediatric radiology2019
Performance of two--dimensional ultrasound shear wave elastography: reference values of normal liver stiffness in children.
Article in Pediatric radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07731360 (A Non-Invasive Diagnostic Panel for MASLD in Children With Obesity), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Non-Invasive Diagnostic Panel for MASLD in Children With Obesity: Evaluation of a Multiparametric Biomarker Panel and Genetic Risk Score Using LASSO-Regularized Logistic Regression - The PedMASLD-MultiOmics Pilot Study
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Diagnostic accuracy of two-dimensional shear wave elastography in detecting hepatic fibrosis in children with autoimmune hepatitis, biliary atresia and other chronic liver diseases.Pediatric radiology · 2021Pooled it
- Normal liver stiffness values measured with MR elastography and two-dimensional shear wave elastography in children aged 9-17 years.Abdominal radiology (New York) · 2026Article
- Fontan-associated liver disease: The role of liver elastography assessments pre- and post-heart transplant.Journal of pediatric gastroenterology and nutrition · 2026Article
- Reference values for shear wave elastography, shear wave dispersion and attenuation imaging in healthy paediatric livers.Pediatric radiology · 2026Article
- Pediatric MASLD in Severe Obesity: Current Clinical Perspectives on Diagnosis and Treatment.Journal of clinical medicine · 2025Review
- Reference Values for Liver Stiffness in Newborns by Gestational Age, Sex, and Weight Using Three Different Elastography Methods.Journal of clinical medicine · 2025Article
- Changes in Liver Shear Wave Elastography of Preterm Infants during Hospitalization.American journal of perinatology · 2025Article
- Two-dimensional shear wave elastography for assessing liver, spleen, and kidneys in healthy newborns.Journal of ultrasonography · 2025Article
- Evaluation of Hepatic Shear Wave Elastography to Assess Liver Fibrosis in Biliary Atresia Patients and Its Correlation with Liver Histology and Surgical Outcomes: A Prospective Observational Study.The Indian journal of radiology & imaging · 2024Article
- Weight-specific normal liver stiffness values in children.Pediatric radiology · 2024Article
- Evaluation of Hepatosteatosis-Induced Increase in Fibrosity by Two-Dimensional Shear Wave Elastography in Children with Obesity and Comparison with Healthy Peers.Turkish archives of pediatrics · 2024Article
- Article
- Liver and kidney ultrasound elastography in children and young adults with hypertension or chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Liver cirrhosis in children - the role of imaging in the diagnostic pathway.Pediatric radiology · 2023Article
- Clinical study of the value of shear wave elastography in evaluating the degree of liver fibrosis in children.Abdominal radiology (New York) · 2023Article
- Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation.Ultrasonography (Seoul, Korea) · 2023Article
- Liver fibrosis in children: a comprehensive review of mechanisms, diagnosis, and therapy.Clinical and experimental pediatrics · 2023Article
- Validation of attenuation imaging coefficient, shear wave elastography, and dispersion as emerging tools for non-invasive evaluation of liver tissue in children.Frontiers in pediatrics · 2023Article
- Defining values for controlled attenuation parameter and liver stiffness in youth without liver disease.Pediatric research · 2022Article
- Shear Wave Elastography in the Differentiation of Nonfibrotic Versus Fibrotic Liver Disease in Children: A Prospective Study With Histological Correlation.JPGN reports · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTwo-dimensional (2-D) shear wave elastography is a new sonographic elastography method for noninvasive measurement of liver stiffness.
objectiveThe aim of this study was to establish reference values of normal liver stiffness on 2-D shear wave elastography in children. MATERIALS AND
methodsTwo-dimensional shear wave elastography values were measured in 202 children with no liver disease from the neonatal period to puberty, who were divided into 4 age groups: newborns and infants, preschoolers, elementary school children and adolescents. We investigated the effects of age, depth of elastography measurement, transducer, number of measurements per child, liver size and Doppler parameters of hepatic blood flow on liver elasticity values.
resultsThe mean normal liver elasticity value in the study population was: 4.29±0.59 kilopascals (kPa). In neonates and infants, mean liver elasticity value was 4.63 (± 0.6) kPa, in preschoolers and elementary school children, 4.05 (± 0.57) kPa and 4.15 (± 0.52) kPa, respectively, and in adolescents, 4.39 (± 0.55) kPa. Values in neonates and infants as well as adolescents were significantly higher than in preschoolers and elementary school children (Kruskal-Wallis, P<0.001; Mann-Whitney U tests, P<0.05). There was no significant association between liver elasticity values and size of the right lobe or Doppler parameters of hepatic blood flow. Different depths and the number of elastography measurements had no effect on liver elasticity values.
conclusionTwo-dimensional shear wave elastography is achievable in a wide range of age in children. We established the reference values of normal liver stiffness on 2-D shear wave elastography in children.
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