ArticleJournal of biomechanical engineering2019
Regularization-Free Strain Mapping in Three Dimensions, With Application to Cardiac Ultrasound.
Article in Journal of biomechanical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Tension anisotropy drives fibroblast phenotypic transition by self-reinforcing cell-extracellular matrix mechanical feedback.Nature materials · 2025Article
- Deep learning enables accurate soft tissue tendon deformation estimation in vivo via ultrasound imaging.Scientific reports · 2024Article
- Downregulation of RIP3 ameliorates the left ventricular mechanics and function after myocardial infarctionOpen life sciences · 2024Article
- MicroBundleCompute: Automated segmentation, tracking, and analysis of subdomain deformation in cardiac microbundles.PloS one · 2024Article
- Virtual blebbistatin: A robust and rapid software approach to motion artifact removal in optical mapping of cardiomyocytes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mechanobiology of cancer cell responsiveness to chemotherapy and immunotherapy: Mechanistic insights and biomaterial platforms.Advanced drug delivery reviews · 2023Review
- Localized strain characterization of cardiomyopathy in Duchenne muscular dystrophy using novel 4D kinematic analysis of cine cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- An ex vivo culture model of kidney podocyte injury reveals mechanosensitive, synaptopodin-templating, sarcomere-like structures.Science advances · 2022Article
- Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue.Nature communications · 2020Article
- Label-free photoacoustic and ultrasound imaging for murine atherosclerosis characterization.APL bioengineering · 2020Article
- Three-dimensional myocardial strain correlates with murine left ventricular remodelling severity post-infarction.Journal of the Royal Society, Interface · 2019Article
- High-frequency murine ultrasound provides enhanced metrics of BAPN-induced AAA growth.American journal of physiology. Heart and circulatory physiology · 2019Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Quantifying dynamic strain fields from time-resolved volumetric medical imaging and microscopy stacks is a pressing need for radiology and mechanobiology. A critical limitation of all existing techniques is regularization: because these volumetric images are inherently noisy, the current strain mapping techniques must impose either displacement regularization and smoothing that sacrifices spatial resolution, or material property assumptions that presuppose a material model, as in hyperelastic warping. Here, we present, validate, and apply the first three-dimensional (3D) method for estimating mechanical strain directly from raw 3D image stacks without either regularization or assumptions about material behavior. We apply the method to high-frequency ultrasound images of mouse hearts to diagnose myocardial infarction. We also apply the method to present the first ever in vivo quantification of elevated strain fields in the heart wall associated with the insertion of the chordae tendinae. The method shows promise for broad application to dynamic medical imaging modalities, including high-frequency ultrasound, tagged magnetic resonance imaging, and confocal fluorescence microscopy.
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Registered trials
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