ArticleScientific reports2018
Excitability regulation in the dorsomedial prefrontal cortex during sustained instructed fear responses: a TMS-EEG study.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Cortical dysfunction and impulsivity in non-suicidal self-injury: a multimodal study using TMS-EEG and fNIRS.Annals of medicine · 2025Article
- Directional flow of brain connections and neurodevelopmental outcomes in healthy full-term newborns.Neuroscience letters · 2025Article
- An ERP study on verb bias and thematic role assignment in standard Indonesian.Scientific reports · 2025Article
- Altered cortical synaptic lipid signaling leads to intermediate phenotypes of mental disorders.Molecular psychiatry · 2024Article
- The Past, Current and Future Research in Cerebellar TMS Evoked Responses-A Narrative Review.Brain sciences · 2024Review
- The ventromedial prefrontal cortex in response to threat omission is associated with subsequent explicit safety memory.Scientific reports · 2024Article
- Modular segregation drives causality of the dynamic oscillatory network responses during threat processing.Brain communications · 2023Article
- Network alterations underlying anxiety symptoms in early multiple sclerosis.Journal of neuroinflammation · 2022Article
- Inhibitory and excitatory responses in the dorso-medial prefrontal cortex during threat processing.Frontiers in neuroscience · 2022Article
- Gray Matter Density of the Dorsomedial Prefrontal Cortex Mediates the Relationship Between Catastrophizing and Anxiety in Somatic Symptom Disorder.Neuropsychiatric disease and treatment · 2021Article
- Exciting Complexity: The Role of Motor Circuit Elements in ALS Pathophysiology.Frontiers in neuroscience · 2020Review
- Cortical Excitability Dynamics During Fear Processing.Frontiers in neuroscience · 2019Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Threat detection is essential for protecting individuals from adverse situations, in which a network of amygdala, limbic regions and dorsomedial prefrontal cortex (dmPFC) regions are involved in fear processing. Excitability regulation in the dmPFC might be crucial for fear processing, while abnormal patterns could lead to mental illness. Notwithstanding, non-invasive paradigms to measure excitability regulation during fear processing in humans are missing. To address this challenge we adapted an approach for excitability characterization, combining electroencephalography (EEG) and transcranial magnetic stimulation (TMS) over the dmPFC during an instructed fear paradigm, to dynamically dissect its role in fear processing. Event-related (ERP) and TMS-evoked potentials (TEP) were analyzed to trace dmPFC excitability. We further linked the excitability regulation patterns to individual MRI-derived gray matter structural integrity of the fear network. Increased cortical excitability was demonstrated to threat (T) processing in comparison to no-threat (NT), reflected by increased amplitude of evoked potentials. Furthermore, TMS at dmPFC enhanced the evoked responses during T processing, while the structural integrity of the dmPFC and amygdala predicted the excitability regulation patterns to fear processing. The dmPFC takes a special role during fear processing by dynamically regulating excitability. The applied paradigm can be used to non-invasively track response abnormalities to threat stimuli in healthy subjects or patients with mental disorders.
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