Evidence map›Paper›PMID 30266987›Full record

ArticleScientific reports2018

GLS-409, an Antagonist of Both P2Y

Elena Smolensky Koganov, Alan D Michelson, Ivan B Yanachkov, Milka I Yanachkova, George E Wright, Karin Przyklenk, Andrew L Frelinger

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Advances in nucleotide-based P2Y₁ antagonism: implications for cardiovascular therapeutics.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Platelet P2YBMC biology · 2023
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elena Smolensky KoganovCenter for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.
Alan D MichelsonCenter for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.
Ivan B YanachkovGLSynthesis Inc., Worcester, MA, USA.
Milka I YanachkovaGLSynthesis Inc., Worcester, MA, USA.
George E WrightGLSynthesis Inc., Worcester, MA, USA.
Karin PrzyklenkCardiovascular Research Institute and Departments of Physiology and Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
Andrew L FrelingerCenter for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA. Andrew.Frelinger@childrens.harvard.edu.
Glsynthesis · USHarvard University · USWayne State University · US

Funding

Novel Antithrombotic Diadenosine Tetraphosphate AnalogsR44HL088828 · NHLBI · GLSYNTHESIS, INC. · PI YANACHKOV, IVAN B · 2009 to 2010
$1.5M
Novel Antithrombotic Diadenosine Tetraphosphate AnalogsR43HL088828 · NHLBI · GLSYNTHESIS, INC. · PI YANACHKOV, IVAN B · 2007 to 2007
$333k
NHLBI NIH HHS R43 HL088828NHLBI NIH HHS R44 HL088828
6 · The paper itself

Abstract

Dual antiplatelet therapy with aspirin and an adenosine diphosphate (ADP) P2Y

Indexed as

AnimalsCoronary ThrombosisDinucleoside PhosphatesDog DiseasesDogsFemaleHumansPlatelet ActivationPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12diadenosine tetraphosphateDinucleoside PhosphatesPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12

Identifiers

PMID30266987
PMCPMC6162268
OpenAlexW2892418006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.