Evidence map›Paper›PMID 30266983›Full record

ArticleScientific reports2018

A Novel iRFP-Incorporated in vivo Murine Atherosclerosis Imaging System.

Kaushalya Kulathunga, Michito Hamada, Yukiko Hiraishi, Mao Otake, Mai Thi Nhu Tran, Olivia Cheng, Junko Tanaka, Tomoki Sakasai, Shota Sakaguchi, Yuka Sugiyama and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kaushalya KulathungaDepartment of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Michito HamadaDepartment of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. hamamichi@md.tsukuba.ac.jp.ORCID http://orcid.org/0000-0002-4737-1007
Yukiko HiraishiDepartment of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Mao OtakeDepartment of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Mai Thi Nhu TranDepartment of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Olivia ChengSchool of Medicine, Stony Brook University, Stony Brook, New York, 11794-8036, USA.
Junko TanakaLaboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Tomoki SakasaiLaboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Shota SakaguchiLaboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Yuka SugiyamaLaboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Bernd K FleischmannInstitute of Physiology I, Life & Brain Center, Medical Faculty, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
Satoru TakahashiDepartment of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. satoruta@md.tsukuba.ac.jp.ORCID http://orcid.org/0000-0002-8540-7760
Yoshihiro MiwaLaboratory Animal Resource Center, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Funding

Japan Society for the Promotion of Science (JSPS) 16K18398
6 · The paper itself

Abstract

By using near-infrared fluorescent protein (iRFP)-expressing hematopoietic cells, we established a novel, quantitative, in vivo, noninvasive atherosclerosis imaging system. This murine atherosclerosis imaging approach targets macrophages expressing iRFP in plaques. Low-density lipoprotein receptor-deficient (LDLR

Indexed as

ActinsAnimalsAortic DiseasesAtherosclerosisAzo CompoundsBone Marrow TransplantationCholesterol, DietaryColoring AgentsFlow CytometryGenes, ReporterGenes, SyntheticLuminescent MeasurementsLuminescent ProteinsMacrophages, PeritonealMiceMice, TransgenicActinsAzo CompoundsCholesterol, DietaryColoring AgentsLuminescent Proteinsoil red OReceptors, LDLRecombinant Proteins

Identifiers

PMID30266983
PMCPMC6162307

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.