Evidence map›Paper›PMID 30266981›Full record

ArticleNature communications2018

Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus.

Allison Sang, Thomas Danhorn, Jacob N Peterson, Andrew L Rankin, Brian P O'Connor, Sonia M Leach, Raul M Torres, Roberta Pelanda

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Allison SangDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Thomas DanhornCenter for Genes, Environment and Health, National Jewish Health, Denver, CO, 80206, USA.ORCID http://orcid.org/0000-0002-3861-8602
Jacob N PetersonDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Andrew L RankinInflammation and Immunology, Pfizer Research, Cambridge, MA, 02140, USA.
Brian P O'ConnorDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Sonia M LeachCenter for Genes, Environment and Health, National Jewish Health, Denver, CO, 80206, USA.
Raul M TorresDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Roberta PelandaDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA. Roberta.Pelanda@ucdenver.edu.
National Jewish Health · USUniversity of Colorado Denver · USPfizer (United States) · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Chemokine response in B cell development and functionR01AI052157 · NIAID · UNIVERSITY OF COLORADO DENVER · PI TORRES, RAUL MARTIN · 2002 to 2017
$5.4M
Tolerance in Polyclonal and Oligoclonal Immune SystemsR01AI052310 · NIAID · UNIVERSITY OF COLORADO DENVER · PI PELANDA, ROBERTA · 2003 to 2017
$5.0M
Molecular Mechanisms of Immune ToleranceT32AI074491 · NIAID · NATIONAL JEWISH HEALTH · PI CAMBIER, JOHN C, PELANDA, ROBERTA · 2009 to 2023
$4.1M
Humoral Immunity by Anergic B cellsR01AI136534 · NIAID · UNIVERSITY OF COLORADO DENVER · PI TORRES, RAUL MARTIN · 2018 to 2022
$2.6M
Marginal Zone B Cell Response to HIVR21AI078468 · NIAID · UNIVERSITY OF COLORADO DENVER · PI TORRES, RAUL MARTIN · 2008 to 2009
$424k
Tolerance in Polyclonal and Oligoclonal Immune SystemsR56AI052310 · NIAID · NATIONAL JEWISH HEALTH · PI PELANDA, ROBERTA · 2007 to 2007
$363k
NCI NIH HHS P30 CA046934NIAID NIH HHS R01 AI052157NIAID NIH HHS R01 AI052310NIAID NIH HHS R01 AI136534NIAID NIH HHS R21 AI078468NIAID NIH HHS R56 AI052310NIAID NIH HHS T32 AI074491
6 · The paper itself

Abstract

Autoreactive B cells have a major function in autoimmunity. A small subset of B cells expressing two distinct B-cell-antigen-receptors (B

Indexed as

Cell ProliferationAdaptive ImmunityAnimalsAutoantibodiesAutoimmunityB-Lymphocyte SubsetsCell DifferentiationHomeostasisImmunity, InnateInterleukin-21InterleukinsLupus Erythematosus, SystemicMice, Inbred MRL lprMice, KnockoutReceptors, Antigen, B-CellSignal TransductionAutoantibodiesInterleukin-21InterleukinsReceptors, Antigen, B-Cell

Identifiers

PMID30266981
PMCPMC6162205
OpenAlexW2892470330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.