ArticleScientific reports2018
More Prevalent Prescription of Medicine for Hypertension and Metabolic Syndrome in Males from Couples Undergoing Intracytoplasmic Sperm Injection.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Male infertility and risk of cardiometabolic conditions: a population-based cohort study.Human reproduction (Oxford, England) · 2026Article
- Are young men attempting to achieve paternity through intracytoplasmic sperm injection candidates for general health screenings?International journal of impotence research · 2025Article
- Male Infertility and Reduced Life Expectancy: Epidemiology, Mechanisms, and Clinical Implications.Journal of clinical medicine · 2025Review
- Prevalence of impaired renal function among childless men as compared to fathers: a population-based study.Scientific reports · 2024Article
- Testosterone deficiency and metabolic disturbances in men who fathered a child by use of donated spermatozoa.Scientific reports · 2022Article
- Metabolic syndrome and male fertility disorders: Is there a causal link?Reviews in endocrine & metabolic disorders · 2021Review
- Impact of genetic risk score on the association between male childlessness and cardiovascular disease and mortality.Scientific reports · 2021Article
- Metabolic Syndrome and Reproduction.International journal of molecular sciences · 2021Review
- Sperm biology and male reproductive health.Scientific reports · 2020Article
- Testosterone replacement therapy in men who conceived with intracytoplasmic sperm injection: nationwide register study.European journal of endocrinology · 2020Article
- Hypertension and Reproduction.Current hypertension reports · 2020Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Register-based studies have indicated that men with impaired fertility are at higher risk for developing various adult-onset diseases than fertile men. The majority of men undergoing ICSI treatment are sub-fertile and since they are in contact with the health care system, these men are well suited as target for preventive measures. Our study included all men (N = 459 766) who had fathered children in Sweden between 2006 and 2016. Swedish registry data was used for obtaining information regarding conception method and defining three groups of fathers - ICSI -treated, IVF - treated and non IVF/ICSI. By sourcing data from the Swedish Prescribed Drug Register, we specifically searched for information regarding prescription and usage of at least one prescription for diabetes mellitus, hypertension (HT) or dyslipidemia to serve as a proxy for metabolic disease among the study groups. If all three types of medicine were prescribed, the patient was considered as having metabolic syndrome. Our results indicate male partners in couples who became parents using ICSI to be at higher risk for being treated for hypertension (HR = 1.15 95% CI: 1.06-1.24, p = 0.001) and metabolic syndrome (HR = 1.28 95% CI: 1.01-1.58, p = 0.042) when compared to non IVF/ICSI men.
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Registered trials
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