Evidence map›Paper›PMID 30266951›Full record

ArticleNature communications2018

Structural basis of neurosteroid anesthetic action on GABA

Qiang Chen, Marta M Wells, Palaniappa Arjunan, Tommy S Tillman, Aina E Cohen, Yan Xu, Pei Tang

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
  2. A pore-facing glycan constrains GABACommunications biology · 2026
    Article
  3. Direct modulation of human GABA-A αFrontiers in neuroscience · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Neurosteroid Binding and Actions on GABAJuntendo Iji zasshi = Juntendo medical journal · 2024
    Review
  16. Epileptic EncephalopathyBiomolecules · 2023
    Article
  17. Article
  18. Article
  19. Allosteric modulation of α1β3γ2 GABABiophysical journal · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Qiang ChenDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA.ORCID http://orcid.org/0000-0002-6524-9849
Marta M WellsDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Palaniappa ArjunanDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Tommy S TillmanDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Aina E CohenStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.
Yan XuDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA.ORCID http://orcid.org/0000-0003-2773-8024
Pei TangDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA. ptang@pitt.edu.
University of Pittsburgh · USSLAC National Accelerator Laboratory · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
ANESTHETIC SITES IN TRANSMEMBRANE PEPTIDES BY NMRR01GM056257 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TANG, PEI · 1998 to 2017
$4.8M
Integrated Interdisciplinary, inter-university PhD Program Computational Biology (T32)T32EB009403 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAHAR, IVET, BAR-JOSEPH, ZIV · 2009 to 2023
$4.4M
National Science Foundation (NSF) TG-MCB050030NNIBIB NIH HHS T32 EB009403NIGMS NIH HHS P41 GM103393NIGMS NIH HHS R01 GM056257U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM056257
6 · The paper itself

Abstract

Type A γ-aminobutyric acid receptors (GABA

Indexed as

Molecular Dynamics SimulationAmino Acid SequenceAnestheticsAnimalsBinding SitesCrystallography, X-RayFemaleHumansIon Channel GatingOocytesPregnanedionesReceptors, GABA-ASequence Homology, Amino AcidXenopus laevisalphaxaloneAnestheticsPregnanedionesReceptors, GABA-A

Identifiers

PMID30266951
PMCPMC6162318
OpenAlexW2892600712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.