Evidence map›Paper›PMID 30266921›Full record

ArticleScientific reports2018

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis.

Sally K Martin, Stephen Fitter, Nadia El Khawanky, Randall H Grose, Carl R Walkley, Louise E Purton, Markus A Ruegg, Michael N Hall, Stan Gronthos, Andrew C W Zannettino

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Whole-Genome Sequencing Unveils the Uniqueness of Yushu Yaks (International journal of molecular sciences · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Deletion ofFrontiers in immunology · 2022
    Article
  7. The crosstalk between MYC and mTORC1 during osteoclastogenesis.Frontiers in cell and developmental biology · 2022
    Article
  8. Review
  9. Deletion ofJBMR plus · 2021
    Article
  10. Review
  11. Article
  12. Current Understanding of Osteoimmunology in Certain Osteoimmune Diseases.Frontiers in cell and developmental biology · 2021
    Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Sally K MartinMyeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.
Stephen FitterMyeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.
Nadia El KhawankyThe South Australian Health and Medical Research Institute, Adelaide, Australia.
Randall H GroseThe South Australian Health and Medical Research Institute, Adelaide, Australia.
Carl R WalkleyStem Cell Regulation Unit, St Vincent's Institute of Medical Research, Melbourne, Australia.ORCID http://orcid.org/0000-0002-4784-9031
Louise E PurtonStem Cell Regulation Unit, St Vincent's Institute of Medical Research, Melbourne, Australia.ORCID http://orcid.org/0000-0001-6593-3168
Markus A RueggBiozentrum, University of Basel, Basel, Switzerland.
Michael N HallBiozentrum, University of Basel, Basel, Switzerland.
Stan GronthosThe South Australian Health and Medical Research Institute, Adelaide, Australia.ORCID http://orcid.org/0000-0002-6225-3084
Andrew C W ZannettinoMyeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia. andrew.zannettino@adelaide.edu.au.
South Australian Health and Medical Research Institute · AUSt Vincents Institute of Medical Research · AUUniversity of Basel · CHUniversity of Freiburg · DE

Funding

Department of Health | National Health and Medical Research Council (NHMRC) APP1030528
6 · The paper itself

Abstract

Skeletal osteoblasts are important regulators of B-lymphopoiesis, serving as a rich source of factors such as CXCL12 and IL-7 which are crucial for B-cell development. Recent studies from our laboratory and others have shown that deletion of Rptor, a unique component of the mTORC1 nutrient-sensing complex, early in the osteoblast lineage development results in defective bone development in mice. In this study, we now demonstrate that mTORC1 signalling in pre-osteoblasts is required for normal B-lymphocyte development in mice. Targeted deletion of Rptor in osterix-expressing pre-osteoblasts (Rptor

Indexed as

AnimalsB-LymphocytesChemokine CXCL12Coculture TechniquesDown-RegulationGenes, ReporterInterleukin-7LymphopoiesisMechanistic Target of Rapamycin Complex 1MiceMice, KnockoutMice, TransgenicOsteoblastsRegulatory-Associated Protein of mTORRNA, MessengerSp7 Transcription FactorChemokine CXCL12Cxcl12 protein, mouseInterleukin-7interleukin-7, mouseMechanistic Target of Rapamycin Complex 1Regulatory-Associated Protein of mTORRNA, MessengerRptor protein, mouseSp7 protein, mouseSp7 Transcription Factor

Identifiers

PMID30266921
PMCPMC6162303
OpenAlexW2894507864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.