ReviewThe American journal of case reports2018
Idiosyncratic Drug-Induced Liver Injury Due to Ciprofloxacin: A Report of Two Cases and Review of the Literature.
Review in The American journal of case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- The effects of environmentally relevant concentrations of enrofloxacin on growth performance, oxidative stress, and mRNA expression of apoptotic enzymes (caspase-3, caspase-8)/pro-inflammatory cytokines (IL-1β, TNF-β, and IL-6) in gills of Oreochromis niloticus.Fish physiology and biochemistry · 2025Article
- Article
- Drug-Induced Liver Injury with Commonly Used Antibiotics in the All of Us Research Program.Clinical pharmacology and therapeutics · 2023Article
- IgG4-related autoimmune hepatitis: A case report.The Journal of international medical research · 2023Article
- Drug-Induced Liver Injury in Hospitalized Patients during SARS-CoV-2 Infection.Medicina (Kaunas, Lithuania) · 2022Review
- Acute Immunoallergic Hepatitis in the Presence of Crohn's Disease: A Case Presentation and Review of the Literature.Cureus · 2022Article
- Drug-induced severe liver injury due toJournal of biomedical research · 2022Article
- Systemic quinolones and risk of acute liver failure I: Analysis of data from the US FDA adverse event reporting system.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Hepatotoxicity Secondary to Levofloxacin Use.Cureus · 2021Article
- Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review.European journal of clinical pharmacology · 2021Review
- Article
- Jaundice may be the only clinical manifestation of primary hepatosplenic diffuse large B-cell lymphoma: a case report and literature review.The Journal of international medical research · 2020Review
- Hepatotoxicty of Agents Used in the Management of Inflammatory Bowel Disease: a 2020 Update.Current gastroenterology reports · 2020Review
- Time event ontology (TEO): to support semantic representation and reasoning of complex temporal relations of clinical events.Journal of the American Medical Informatics Association : JAMIA · 2020Article
- Clinical Characteristics of 162 Patients with Drug-Induced Liver and/or Kidney Injury.BioMed research international · 2020Article
- Comparison of Methicillin-ResistantJournal of clinical medicine · 2019Article
- Drug-Induced Liver Injury Caused by Capecitabine: A Case Report and a Literature Review.Case reports in oncologyArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Drug-induced liver injury (DILI) can present clinically as a spectrum that includes asymptomatic elevation of transaminases, acute or chronic hepatitis, and acute liver failure. Idiosyncratic DILI is more likely to affect individuals with comorbidities, and to have a wide range of clinical presentations. Although antibiotics are associated with DILI, the fluoroquinolone, ciprofloxacin, is a rarely reported cause. Two cases of idiosyncratic DILI following ciprofloxacin treatment are described, including a review of the literature. CASE REPORT Case 1: A 35-year-old man was treated with ciprofloxacin for periorbital cellulitis. On the second day of ciprofloxacin treatment, he developed abdominal pain, nausea, vomiting and increased serum levels of liver transaminases, aspartate aminotransferase (AST), and alanine aminotransferase (ALT). Further investigations excluded infectious hepatitis, autoimmune disease, or structural liver disease. Exclusion of other causes of DILI and cessation of ciprofloxacin resulted in clinical improvement and normalization of liver function tests (LFTs). Case 2: An 82-year-old man was treated with ciprofloxacin for osteomyelitis. On the tenth day of ciprofloxacin treatment, he developed jaundice and abnormal LFTs, including increased AST, ALT, alkaline phosphatase (ALP), and total bilirubin. Further investigations excluded infectious hepatitis, autoimmune disease, or structural liver disease. Exclusion of other causes of DILI and cessation of ciprofloxacin resulted in clinical improvement and normalization of LFTs. CONCLUSIONS Idiosyncratic DILI due to ciprofloxacin treatment is rare. These two cases have shown that timely diagnosis and discontinuation of ciprofloxacin can prevent the progression of DILI, reduce liver damage, and reduce mortality rates from DILI.
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