ArticleNeurology2018
Pregnancy rates and outcomes in women with and without MS in the United States.
Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07011875 (The Effect of Physical Activity Levels on Dysmenorrhea Severity, Menstrual Symptoms, and Functional and Emotional Status in Women Diagnosed With Multiple Sclerosis), which is not on this map. Cited by 41 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Physical Activity Levels on Dysmenorrhea Severity, Menstrual Symptoms, and Functional and Emotional Status in Women Diagnosed With Multiple Sclerosis
Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The prevalence of mental health-related multimorbidity during pregnancy: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Meta-synthesis of the motherhood-related needs of women with multiple sclerosis.BMC women's health · 2024Pooled it
- Potential Protective Role of Pregnancy and Breastfeeding in Delaying Onset Symptoms Related to Multiple Sclerosis.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Multiple Sclerosis in Pregnancy and its Role in Female Fertility: A Systematic Review.JBRA assisted reproduction · 2021Pooled it
- Reduced childbirth rates in multiple sclerosis from the prodromal phase: Evidence from a population-based cohort study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- A Real-World Prospective Multiple Sclerosis Pregnancy Registry in the United States: PREG-MS.Neurology. Clinical practice · 2025Article
- Understanding the meaning of the lived experience "maternal role" in women with multiple sclerosis and planning a supportive program: a combined exploratory study protocol.Reproductive health · 2024Article
- Multiple sclerosis and abnormal spermatozoa: A bidirectional two-sample mendelian randomization study.PloS one · 2024Article
- Article
- Assisted Reproductive Technology and Disease Management in Infertile Women with Multiple Sclerosis.CNS drugs · 2023Review
- Pregnancy prevalence and outcomes after optic neuritis in South Korea.Scientific reports · 2023Article
- [Family planning in men and women with multiple sclerosis. Analysis of the Andalusian Registry (2018-2022)].Revista de neurologia · 2023Observational
- Multiple sclerosis, disease-modifying drugs and risk for adverse perinatal and pregnancy outcomes: Results from a population-based cohort study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Expert opinion on the pharmacological management of multiple sclerosis in women of childbearing age in Iraq.Heliyon · 2023Review
- Optimizing the "Time to pregnancy" in women with multiple sclerosis: the OPTIMUS Delphi survey.Frontiers in neurology · 2023Article
- The Rate of Hospitalization of Pregnant Women with Multiple Sclerosis in Poland.Journal of clinical medicine · 2022Article
- Trends in the use of disease-modifying therapies among reproductive-aged women with multiple sclerosis in the United States from 2010 to 2019.Pharmacoepidemiology and drug safety · 2022Article
- Updated Perspectives on the Challenges of Managing Multiple Sclerosis During Pregnancy.Degenerative neurological and neuromuscular disease · 2022Review
- Multiple Sclerosis Impact on Pregnancy: An Update on Management Issues : Management of MS During Pregnancy.Galen medical journal · 2022Review
- Interferons and Multiple Sclerosis: Lessons from 25 Years of Clinical and Real-World Experience with Intramuscular Interferon Beta-1a (Avonex).CNS drugs · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare pregnancy prevalence and complications in women with and without multiple sclerosis (MS).
methodsThis retrospective US administrative claims study used data from January 1, 2006, to June 30, 2015. All data for women with MS were included. A nationally representative 5% random sample from approximately 58 million women without MS was used to compute the dataset. Annual pregnancy rates, identified via diagnosis/procedure codes and adjusted for covariates, were estimated via logistic regression. Claims for pregnancy and labor/delivery complications were compared using propensity score matching.
resultsFrom 2006 to 2014, the adjusted proportion of women with MS and pregnancy increased from 7.91% to 9.47%; the adjusted proportion without MS and with pregnancy decreased from 8.83% to 7.75%. The difference in linear trend (0.17% increase and 0.15% decrease in per-annum pregnancy rates) was significant (
conclusionsPregnancy rates in this population of women with MS have been increasing. High rates of claims for several peripartum complications were observed in women with and those without MS. Claims data provide knowledge of interactions patients have with the health care system and are valuable initial exploratory analyses.
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