ArticleNeurology2018
Relapses and disease-modifying drug treatment in pregnancy and live birth in US women with MS.
Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Potential Protective Role of Pregnancy and Breastfeeding in Delaying Onset Symptoms Related to Multiple Sclerosis.Medicina (Kaunas, Lithuania) · 2023Pooled it
- A systematic review and meta-analyses of pregnancy and fetal outcomes in women with multiple sclerosis: a contribution from the IMI2 ConcePTION project.Journal of neurology · 2020Pooled it
- Association between pregnancy timing and disability outcomes in women with mild relapse-onset multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Use of multiple sclerosis drugs among pregnant individuals with live-birth deliveries in the FDA's Sentinel Distributed Database.BMC pregnancy and childbirth · 2026Article
- Multiple Sclerosis Relapse Treatment During Pregnancy and Offspring Functional and Structural Neurodevelopment: A Cross-Sectional Study.Neurology · 2025Observational
- A Real-World Prospective Multiple Sclerosis Pregnancy Registry in the United States: PREG-MS.Neurology. Clinical practice · 2025Article
- Sex differences in relapse-independent and relapse-associated disability progression in relapsing-remitting multiple sclerosis: a real-world inverse-probability weighted study.Therapeutic advances in neurological disorders · 2025Article
- Pregnant Women with Multiple Sclerosis: An Overview of Gene Expression and Molecular Interaction Using Bioinformatics Analysis.International journal of molecular sciences · 2024Review
- Pregnancy prevalence and outcomes after optic neuritis in South Korea.Scientific reports · 2023Article
- Association of pregnancies with risk of multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Updated Perspectives on the Challenges of Managing Multiple Sclerosis During Pregnancy.Degenerative neurological and neuromuscular disease · 2022Review
- Influence of Pregnancy in Multiple Sclerosis and Impact of Disease-Modifying Therapies.Frontiers in neurology · 2021Review
- Treatment of Women with Multiple Sclerosis Planning Pregnancy.Current treatment options in neurology · 2021Review
- Estimating Risk of Multiple Sclerosis Disease Reactivation in Pregnancy and Postpartum: The VIPRiMS Score.Frontiers in neurology · 2021Article
- MRI activity in MS and completed pregnancy: Data from a tertiary academic center.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Disease activity in pregnancy and postpartum in women with MS who suspended rituximab and natalizumab.Neurology(R) neuroimmunology & neuroinflammation · 2020Observational
- Pregnancy does not modify the risk of MS in genetically susceptible women.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Sex effects across the lifespan in women with multiple sclerosis.Therapeutic advances in neurological disorders · 2020Review
- Reproductive history and progressive multiple sclerosis risk in women.Brain communications · 2020Article
- Relapses and obstetric outcomes in women with multiple sclerosis planning pregnancy.Journal of neurology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate relapse rates and disease-modifying drug (DMD) treatment in US women with multiple sclerosis (MS) and a live birth.
methodsThis retrospective administrative claims database study used US commercial health plan data from women with MS and a live birth from January 1, 2006, to June 30, 2015. Relapses and DMD treatment were evaluated 1-year prepregnancy, during pregnancy, during puerperium (6 weeks postpregnancy), and 1-year postpregnancy. Relapse was defined as MS-related hospitalization, emergency room visit, or outpatient visit with corticosteroid prescription within 7 days. Generalized estimating equation models for longitudinal data tested for differences between prepregnancy vs the other time periods.
resultsA total of 2,158 patients were eligible. The odds of relapse declined during pregnancy (odds ratio [OR] 0.623, 95% confidence interval [CI] 0.521-0.744;
conclusionsThe rate of MS relapse decreased during pregnancy, increased 6 months postpartum, and decreased 6 to 12 months postpartum. DMD treatment was uncommon in the year before pregnancy, further decreased immediately prepregnancy and during pregnancy, and increased postpartum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.