Evidence map›Paper›PMID 30266874›Full record

Trial reportArchives of disease in childhood2019

Linear growth following complicated severe malnutrition: 1-year follow-up cohort of Kenyan children.

Moses M Ngari, Per Ole Iversen, Johnstone Thitiri, Laura Mwalekwa, Molline Timbwa, Greg W Fegan, James Alexander Berkley

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Archives of disease in childhood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  20. Weight-for-HeightCurrent developments in nutrition · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Moses M NgariKEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.ORCID 0000-0001-7149-549
Per Ole IversenDepartment of Nutrition, IBM, University of Oslo, Oslo, Norway.
Johnstone ThitiriKEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.
Laura MwalekwaKEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.
Molline TimbwaKEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.
Greg W FeganKEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.ORCID 0000-0002-2663-276
James Alexander BerkleyKEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.ORCID 0000-0002-1236-849X

Funding

Medical Research Council MR/M007367/1Wellcome TrustWellcome Trust WT083579MA
6 · The paper itself

Abstract

backgroundStunting is the most common manifestation of childhood undernutrition worldwide. Children presenting with severe acute malnutrition (SAM) are often also severely stunted. We evaluated linear growth and its determinants after medically complicated SAM.

methodsWe performed secondary analysis of clinical trial data

resultsAmong 1169 children with HAZ values at month 12 (66% of those in original trial), median (IQR) age 11 (7-17) months and mean (SD) HAZ -2.87 (1.6) at enrolment, there was no change in mean HAZ between enrolment and month 12: -0.006Z (95% CI -0.07 to 0.05Z). While 262 (23%) children experienced minimal HAZ change (within ±0.25 HAZ), 472 (40%) lost >0.25 and 435 (37%) gained >0.25 HAZ. After adjusting for regression to the mean, inpatient or outpatient episodes of diarrhoea and inpatient severe pneumonia during follow-up were associated with HAZ loss. Premature birth and not being cared by the biological parent were associated with HAZ gain. Increases in mid-upper arm circumference and weight-for-age were associated with HAZ gain and protected against HAZ loss. Increase in weight-for-height was not associated with HAZ gain but protected against HAZ loss. No threshold of weight gain preceding linear catch-up growth was observed.

conclusionsInterventions to improve dietary quality and prevent illness over a longer period may provide opportunities to improve linear growth.

Indexed as

Body HeightChild, PreschoolDouble-Blind MethodFemaleFollow-Up StudiesGrowthGrowth DisordersHumansInfantInfant Nutrition DisordersKenyaMaleSevere Acute Malnutritiongrowthheightmalnutritionstuntingundernutrition

Identifiers

PMID30266874
PMCPMC6556974

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.