Evidence map›Paper›PMID 30266822›Full record

ArticleBlood advances2018

ASXL1 impairs osteoclast formation by epigenetic regulation of NFATc1.

Nidhi Rohatgi, Wei Zou, Patrick L Collins, Jonathan R Brestoff, Timothy H Chen, Yousef Abu-Amer, Steven L Teitelbaum

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

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  14. Monocyte Subsets With High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated by IRF8.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Article
  15. Article
  16. Epigenetic Regulators Involved in Osteoclast Differentiation.International journal of molecular sciences · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nidhi RohatgiDepartment of Pathology and Immunology.
Wei ZouDepartment of Pathology and Immunology.
Patrick L CollinsDepartment of Pathology and Immunology.
Jonathan R BrestoffDepartment of Pathology and Immunology.
Timothy H ChenDepartment of Orthopedic Surgery, and.
Yousef Abu-AmerDepartment of Orthopedic Surgery, and.
Steven L TeitelbaumDepartment of Pathology and Immunology.
Washington University in St. Louis · US

Funding

The Role of the Osteoblast Secretome in Bone FormationP30AR057235 · NIAMS · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2009 to 2018
$5.7M
Mechanisms of AVB3 Integrin Mediated Bone ResorptionR37AR046523 · NIAMS · WASHINGTON UNIVERSITY · PI TEITELBAUM, STEVEN L · 2010 to 2019
$3.3M
Molecular Mechanisms Underlying Tak1 Function in OsteoclastsR01AR054326 · NIAMS · WASHINGTON UNIVERSITY · PI ABU-AMER, YOUSEF · 2008 to 2017
$3.3M
FAT TALKS TO BONER01DK111389 · NIDDK · WASHINGTON UNIVERSITY · PI TEITELBAUM, STEVEN L · 2017 to 2021
$1.9M
Mechanisms of Physiologic and Pathologic OsteoclastogenesisR01AR072623 · NIAMS · WASHINGTON UNIVERSITY · PI ABU-AMER, YOUSEF · 2018 to 2022
$1.7M
NIAMS NIH HHS P30 AR057235NIAMS NIH HHS R01 AR054326NIAMS NIH HHS R01 AR072623NIAMS NIH HHS R37 AR046523NIDDK NIH HHS R01 DK111389
6 · The paper itself

Abstract

Additional sex comb-like 1 (

Indexed as

Epigenesis, GeneticGene Expression Regulation, DevelopmentalAnimalsBinding SitesBone and BonesCell DifferentiationCell LineGene DeletionHistonesHumansMethylationMiceMice, KnockoutModels, BiologicalMyeloid CellsNFATC Transcription FactorsAsxl1 protein, mouseHistonesNFATC Transcription FactorsProto-Oncogene Proteins c-fosRepressor Proteins

Identifiers

PMID30266822
PMCPMC6177649
OpenAlexW2893283158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.