Evidence map›Paper›PMID 30266803›Full record

ArticleDisease models & mechanisms2018

Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies.

Margarita Parada-Kusz, Cristina Penaranda, Elliott J Hagedorn, Anne Clatworthy, Anil V Nair, Jonathan E Henninger, Christoph Ernst, Brian Li, Raquel Riquelme, Humberto Jijon and 4 more

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Benefits of Zebrafish Xenograft Models in Cancer Research.Frontiers in cell and developmental biology · 2021
    Review
  5. Review
  6. Article
  7. Review
  8. Hematopoiesis: A Layered Organization Across Chordate Species.Frontiers in cell and developmental biology · 2020
    Review
  9. Review
  10. Modeling of Solid-Tumor Microenvironment in Zebrafish (Danio Rerio) Larvae.Advances in experimental medicine and biology · 2020
    Review
  11. Modeling hematopoietic disorders in zebrafish.Disease models & mechanisms · 2019
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 5 countries.

Margarita Parada-KuszCenter for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago 8370415, Chile.
Cristina PenarandaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Elliott J HagedornStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Anne ClatworthyBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Anil V NairCenter for Systems Biology, Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Jonathan E HenningerStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Christoph ErnstBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Brian LiStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Raquel RiquelmeStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Humberto JijonGastrointestinal Research Group, Faculty of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.
Eduardo J VillablancaImmunology and Allergy, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm SE-171 76, Sweden.
Leonard I ZonStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0860-926X
Deborah HungBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Miguel L AllendeCenter for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago 8370415, Chile mallende@uchile.cl.ORCID 0000-0002-2783-2152
Boston Children's Hospital · USBroad Institute · USCentre for Genomic Regulation · ESHarvard University · USKarolinska Institutet · SEUniversity of Calgary · CA

Funding

TRANSCRIPTION FACTOR GATA-1 IN TERMINAL ERYTHROID DEVELOPMENTP01HL032262 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI ORKIN, STUART H · 1985 to 2021
$38.9M
Transcriptional mechanisms and melanomaP01CA163222 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Liu · 2013 to 2026
$25.3M
Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David T Scadden · 2017 to 2026
$24.6M
Stem cells for therapeutics discovery in genetic blood disordersU01HL134812 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q, LIPTON, JEFFREY M · 2016 to 2022
$8.3M
Cancer Biology in the ZebrafishR01CA103846 · NCI · CHILDREN'S HOSPITAL BOSTON · PI ZON, LEONARD IRA · 2003 to 2022
$7.5M
Project-002U54DK110805 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI ORKIN, STUART H, ZON, LEONARD IRA · 2016 to 2020
$5.9M
Transcriptional response to signaling during hematopoiesisR01HL144780 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI ZON, LEONARD IRA · 2019 to 2022
$2.1M
Deconstructing the Hematopoietic Stem Cell NicheK01DK111790 · NIDDK · BOSTON MEDICAL CENTER · PI HAGEDORN, ELLIOTT JENNINGS · 2017 to 2021
$792k
NCI NIH HHS P01 CA163222NCI NIH HHS R01 CA103846NHLBI NIH HHS P01 HL032262NHLBI NIH HHS P01 HL131477NHLBI NIH HHS R01 HL144780NHLBI NIH HHS U01 HL134812NIDDK NIH HHS K01 DK111790NIDDK NIH HHS U54 DK110805
6 · The paper itself

Abstract

Xenografts of the hematopoietic system are extremely useful as disease models and for translational research. Zebrafish xenografts have been widely used to monitor blood cancer cell dissemination and homing due to the optical clarity of embryos and larvae, which allow unrestricted

Indexed as

HematopoiesisHost-Pathogen InteractionsAnimalsBacterial InfectionsBlastulaBone Marrow CellsBone Marrow TransplantationCell FusionCell LineageCell MovementCell TrackingChimeraColoring AgentsEmbryo, MammalianEmbryo, NonmammalianFemaleColoring AgentsCell migrationHematopoiesisHost-pathogen interactionsLive imagingXenotransplantationZebrafish

Identifiers

PMID30266803
PMCPMC6262816
OpenAlexW2767628434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.