ArticleJournal of medical genetics2018
Common variants at 5q33.1 predispose to migraine in African-American children.
Article in Journal of medical genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Fine-mapping a genome-wide meta-analysis of 98,374 migraine cases identifies 181 sets of candidate causal variants.Nature communications · 2026Pooled it
- Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.Nature genetics · 2022Pooled it
- Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses.The journal of headache and pain · 2020Pooled it
- Trial
- Do Common Genetic Factors Underlie Comorbidity Between Migraine and Major Depressive Disorder in Youth?Pediatric neurology · 2025Article
- Genetic causal relationship between immune diseases and migraine: a Mendelian randomization study.Frontiers in immunology · 2024Article
- Molecular and Cellular Neurobiology of Circadian and Circannual Rhythms in Migraine: A Narrative Review.International journal of molecular sciences · 2023Review
- Genetics of migraine: where are we now?The journal of headache and pain · 2023Review
- Genetic overlap between temporomandibular disorders and primary headaches: A systematic review.The Japanese dental science review · 2022Review
- Whole-Exome Sequencing Reveals Migraine-Associated Novel Functional Variants in Arab Ancestry Females: A Pilot Study.Brain sciences · 2022Article
- A population-health approach to characterizing migraine by comorbidity: Results from the Mindfulness and Migraine Cohort Study.Cephalalgia : an international journal of headache · 2022Article
- Prioritizing Suggestive Candidate Genes in Migraine: An Opinion.Frontiers in neurology · 2022Article
- Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity.Nature and science of sleep · 2022Article
- A Comprehensive Review on the Role of Genetic Factors in the Pathogenesis of Migraine.Journal of molecular neuroscience : MN · 2021Review
- Identifying genetic variants for age of migraine onset in a Han Chinese population in Taiwan.The journal of headache and pain · 2021Article
- New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis.Communications biology · 2021Article
- Advances in genetics of migraine.The journal of headache and pain · 2019Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundGenome-wide association studies (GWASs) have identified multiple susceptibility loci for migraine in European adults. However, no large-scale genetic studies have been performed in children or African Americans with migraine.
methodsWe conducted a GWAS of 380 African-American children and 2129 ancestry-matched controls to identify variants associated with migraine. We then attempted to replicate our primary analysis in an independent cohort of 233 African-American patients and 4038 non-migraine control subjects.
resultsThe results of this study indicate that common variants at 5q33.1 associated with migraine risk in African-American children (rs72793414, p=1.94×10
conclusionsThis study provides new insights into the genetic basis of childhood migraine and allow for precision therapeutic development strategies targeting migraine patients of African-American ancestry.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.