Evidence map›Paper›PMID 30266735›Full record

ArticleHaematologica2019

Factor VIII cross-matches to the human proteome reduce the predicted inhibitor risk in missense mutation hemophilia A.

Daniel P Hart, Nazmiye Uzun, Stuart Skelton, Alison Kakoschke, Jacob Househam, David S Moss, Adrian J Shepherd

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Translational readthrough atHaematologica · 2023
    Article
  5. Haemophilia.Nature reviews. Disease primers · 2021
    Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Daniel P HartBlizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, London.
Nazmiye UzunDepartment of Biological Sciences and Institute of Structural and Molecular Biology, Birkbeck, University of London, UK.
Stuart SkeltonBlizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, London.
Alison KakoschkeDepartment of Biological Sciences and Institute of Structural and Molecular Biology, Birkbeck, University of London, UK.
Jacob HousehamDepartment of Biological Sciences and Institute of Structural and Molecular Biology, Birkbeck, University of London, UK.
David S MossDepartment of Biological Sciences and Institute of Structural and Molecular Biology, Birkbeck, University of London, UK.
Adrian J ShepherdDepartment of Biological Sciences and Institute of Structural and Molecular Biology, Birkbeck, University of London, UK a.shepherd@mail.cryst.bbk.ac.uk.
Institute of Structural and Molecular Biology · GBBirkbeck, University of London · GBBarts Health NHS Trust · GBQueen Mary University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single missense mutations in the

Indexed as

Mutation, MissenseProteomeAmino Acid SequenceFactor VIIIHemophilia AHLA AntigensHumansIsoantibodiesOligopeptidesProtein BindingProtein Interaction Domains and MotifsProteomicsRisk AssessmentFactor VIIIHLA AntigensIsoantibodiesMHC binding peptideOligopeptidesProteome

Identifiers

PMID30266735
PMCPMC6395325
OpenAlexW2893353895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.