Evidence map›Paper›PMID 30266690›Full record

ArticleFungal genetics and biology : FG & B2018

The contribution of the White Collar complex to Cryptococcus neoformans virulence is independent of its light-sensing capabilities.

Pinkuan Zhu, Alexander Idnurm

Abstract read
In one paragraph

Article in Fungal genetics and biology : FG & B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Molecular mechanisms that govern infection and antifungal resistance in Mucorales.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pinkuan ZhuSchool of Life Sciences, East China Normal University, Shanghai 200241, PR China; School of Biological Sciences, University of Missouri-Kansas City, MO 64110, USA.
Alexander IdnurmSchool of Biological Sciences, University of Missouri-Kansas City, MO 64110, USA; School of BioSciences, The University of Melbourne, VIC 3010, Australia. Electronic address: alexander.idnurm@unimelb.edu.au.

Funding

Antifungal drug target prioritization using Cryptococcus neoformansR21AI094364 · NIAID · UNIVERSITY OF MISSOURI KANSAS CITY · PI IDNURM, ALEXANDER · 2012 to 2013
$409k
NIAID NIH HHS R21 AI094364
6 · The paper itself

Abstract

The White Collar complex is responsible for sensing light and transmitting that signal in many fungal species. In Cryptococcus neoformans and C. deneoformans the complex is involved in protection against damage from ultraviolet (UV) light, repression of mating in response to light, and is also required for virulence. The mechanism by which the Bwc1 photoreceptor contributes to virulence is unknown. In this study, a bwc1 deletion mutant of C. neoformans was transformed with three versions of the BWC1 gene, the wild type, BWC1

Indexed as

CryptococcosisCryptococcus neoformansFungal ProteinsGene Expression Regulation, FungalLightOxygenSignal TransductionVirulenceFungal ProteinsOxygenCryptococcusGalleria mellonellaMedical mycologyPhotobiology

Identifiers

PMID30266690
PMCPMC6252129

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.