ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2019
Perioperative thrombotic complications associated with pediatric liver transplantation: a UNOS database evaluation.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 20 citations in OpenAlex.
- Heparin continuous infusion for thromboprophylaxis in pediatric liver transplant recipients.Frontiers in pediatrics · 2026Article
- Endovascular management of acute portal vein thrombosis in pediatric liver transplant recipients less than 20 kg.Pediatric radiology · 2025Article
- Current Endovascular Management of Arterial Complications After Pediatric Liver Transplantation in a Tertiary Center.Cardiovascular and interventional radiology · 2023Article
- Hyponatremia Is Associated With Increased Mortality in Children on the Waiting List for Liver Transplantation.Transplantation direct · 2020Article
- Hyponatremia Is Protective Against the Development of Portal Vein Thrombosis in Patients Undergoing Liver Transplant.Transplantation proceedingsArticle
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThis retrospective UNOS database evaluation analyzes the prevalence of preoperative portal vein thromboses (PVT), and postoperative thromboses leading to graft failure in pediatric patients undergoing liver transplantation (LT).
methodsThe evaluation was performed in three age groups: I (0-5), II (6-11), III (12-18) years old. Factors predictive of pre- and postoperative thromboses were analyzed.
resultsBetween 2000 and 2015, 8982 pediatric LT were performed in the US. Of those, 390 patients had preoperative PVT (4.3%), and 396 (4.4%) had postoperative thromboses. The prevalence of both types of thromboses was less in Group III than in the other two groups (3.20% vs 4.65%, p = 0.007 and 1.73% vs. 5.13%, p < 0.001, respectively). The prevalence of postoperative thromboses was significantly higher in Group I than in the other two groups (5.49% vs. 2.51%, p < 0.001). Preoperative PVT was independently associated with postoperative thromboses (OR = 1.7, p = 0.02). Children less than 5 years of age were more likely to develop postoperative thromboses leading to graft failure (OR = 2.9, p < 0.001).
conclusionYounger children undergoing LT are prone to pre-and postoperative thrombotic complications. Preoperative PVT at the time of transplantation was independently associated with postoperative thromboses. Perioperative antithrombotic therapy should be considered in pediatric patients undergoing LT.
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