Evidence map›Paper›PMID 30266295›Full record

ArticleEBioMedicine2018

Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism.

Meltem Weger, Benjamin D Weger, Benjamin Görling, Gernot Poschet, Melek Yildiz, Rüdiger Hell, Burkhard Luy, Teoman Akcay, Tülay Güran, Thomas Dickmeis and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Meltem WegerInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: meltem.weger@epfl.ch.
Benjamin D WegerInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Benjamin GörlingInstitute for Organic Chemistry and Institute for Biological Interfaces 4 - Magnetic Resonance, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
Gernot PoschetCentre for Organismal Studies (COS), Heidelberg University, 69120 Heidelberg, Germany.
Melek YildizKanuni Sultan Süleyman Education and Research Hospital, Küçükçekmece, Istanbul, Turkey.
Rüdiger HellCentre for Organismal Studies (COS), Heidelberg University, 69120 Heidelberg, Germany.
Burkhard LuyInstitute for Organic Chemistry and Institute for Biological Interfaces 4 - Magnetic Resonance, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
Teoman AkcayIstinye University Gaziosmanpasa Medical Park Hospital Gaziosmanpasa, Istanbul, Turkey.
Tülay GüranMarmara University, Department of Pediatric Endocrinology and Diabetes, Pendik, Istanbul, Turkey.
Thomas DickmeisInstitute of Toxicology and Genetics, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
Ferenc MüllerInstitute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Nils KroneDepartment of Oncology & Metabolism, University of Sheffield, Sheffield S10 2TH, UK; Department of Biomedical Science, The Bateson Centre, Firth Court, Western Bank, Sheffield S10 2TN, UK.. Electronic address: n.krone@sheffield.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Deficient glucocorticoid biosynthesis leading to adrenal insufficiency is life-threatening and is associated with significant co-morbidities. The affected pathways underlying the pathophysiology of co-morbidities due to glucocorticoid deficiency remain poorly understood and require further investigation. Methods: To explore the pathophysiological processes related to glucocorticoid deficiency, we have performed global transcriptional, post-transcriptional and metabolic profiling of a cortisol-deficient zebrafish mutant with a disrupted ferredoxin ( Findings: Interpretation: Our study provides a detailed map of metabolic changes induced by glucocorticoid deficiency as a consequence of a disrupted ferredoxin system in an animal model of adrenal insufficiency. This improved pathophysiological understanding of global glucocorticoid deficiency informs on more targeted translational studies in humans suffering from conditions associated with glucocorticoid deficiency. Fund: Marie Curie Intra-European Fellowships for Career Development, HGF-programme BIFTM, Deutsche Forschungsgemeinschaft, BBSRC.

Indexed as

Metabolic Networks and PathwaysAdrenal InsufficiencyAnimalsAnimals, Genetically ModifiedGlucocorticoidsGlutamineHumansMetabolomicsZebrafishGlucocorticoidsGlutamineAdrenal insufficiencyFerredoxinOxidative stressPurine metabolismZebrafish

Identifiers

PMID30266295
PMCPMC6197330

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.