ArticleEBioMedicine2018
Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder - A multiplex multigenerational neuroimaging study.
Article in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Pathological fear, anxiety and negative affect exhibit distinct neurostructural signatures: evidence from psychiatric neuroimaging meta-analysis.Translational psychiatry · 2022Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Epidemiology, genetics, neuroimaging, clinical features, and treatment between overall and performance-only social anxiety disorder: a narrative review.Dialogues in clinical neuroscience · 2026Review
- The Impact of Childhood Trauma on Neuropsychological Disorders and Its Intergenerational Transmission Mechanisms.Behavioral sciences (Basel, Switzerland) · 2026Review
- Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Effects of a 12-week dance intervention on left-behind children with co-occurring social anxiety and low self-concept.Frontiers in psychology · 2025Article
- Intergenerational transmission of brain structure and function in humans: a narrative review of designs, methods, and findings.Brain structure & function · 2024Review
- Impact of Stress on Brain Morphology: Insights into Structural Biomarkers of Stress-related Disorders.Current neuropharmacology · 2024Review
- Age-dependent alterations in the coordinated development of subcortical regions in adolescents with social anxiety disorder.European child & adolescent psychiatry · 2024Article
- Altered cortical thickness of the superior frontal gyrus and fusiform gyrus in individuals with subthreshold social anxiety.Scientific reports · 2023Article
- From mother to child: How intergenerational transfer is reflected in similarity of corticolimbic brain structure and mental health.Developmental cognitive neuroscience · 2023Article
- Brain morphometry points to emerging patterns of psychosis, depression, and anxiety vulnerability over a 2-year period in childhood.Psychological medicine · 2023Article
- Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group.Molecular psychiatry · 2023Article
- Intergenerational neuroimaging study: mother-infant functional connectivity similarity and the role of infant and maternal factors.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Intra- and interhemispheric symmetry of subcortical brain structures: a volumetric analysis in the aging human brain.Brain structure & function · 2022Article
- Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): III. Emotional dysfunction superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
- Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder.Translational psychiatry · 2022Article
- ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.Human brain mapping · 2022Review
- Emotional intelligence mediates the association between middle temporal gyrus gray matter volume and social anxiety in late adolescence.European child & adolescent psychiatry · 2021Article
- Subclinical Anxiety and Posttraumatic Stress Influence Cortical Thinning During Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSocial anxiety disorder (SAD) is a disabling psychiatric condition with a genetic background. Brain alterations in gray matter (GM) related to SAD have been previously reported, but it remains to be elucidated whether GM measures are candidate endophenotypes of SAD. Endophenotypes are measurable characteristics on the causal pathway from genotype to phenotype, providing insight in genetically-based disease mechanisms. Based on a review of existing evidence, we examined whether GM characteristics meet two endophenotype criteria, using data from a unique sample of SAD-patients and their family-members of two generations. First, we investigated whether GM characteristics co-segregate with social anxiety within families genetically enriched for SAD. Secondly, heritability of the GM characteristics was estimated.
methodsFamilies with a genetic predisposition for SAD participated in the Leiden Family Lab study on SAD; T1-weighted MRI brain scans were acquired (n = 110, 8 families). Subcortical volumes, cortical thickness and cortical surface area were determined for a-priori determined regions of interest (ROIs). Next, associations with social anxiety and heritabilities were estimated.
findingsSeveral subcortical and cortical GM characteristics, derived from frontal, parietal and temporal ROIs, co-segregated with social anxiety within families (uncorrected p-level) and showed moderate to high heritability.
interpretationThese findings provide preliminary evidence that GM characteristics of multiple ROIs, which are distributed over the brain, are candidate endophenotypes of SAD. Thereby, they shed light on the genetic vulnerability for SAD. Future research is needed to confirm these results and to link them to functional brain alterations and to genetic variations underlying these GM changes. FUND: Leiden University Research Profile 'Health, Prevention and the Human Life Cycle'.
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